Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/9693
Título
Impact of age on the use of adjuvant treatments in patients undergoing surgery for colorectal cancer: patients with stage III colon or stage II/III rectal cancer
Autor(es)
Sarasqueta, C | Perales, A | Escobar, A | Baré, M | Redondo, M | Fernandez de Larrea-Baz, Nerea ISCIII | Briones, E | Piera, J M | Zunzunegui, Maria Victoria ISCIII | Quintana, J M
Fecha de publicación
2019-07-25
Cita
BMC Cancer. 2019 Jul 25;19(1):735.
Idioma
Inglés
Tipo de documento
research article
Resumen
BACKGROUND: Many older patients don't receive appropriate oncological treatment. Our aim was to analyse whether there are age differences in the use of adjuvant chemotherapy and preoperative radiotherapy in patients with colorectal cancer. METHODS: A prospective cohort study was conducted in 22 hospitals including 1157 patients with stage III colon or stage II/III rectal cancer who underwent surgery. Primary outcomes were the use of adjuvant chemotherapy for stage III colon cancer and preoperative radiotherapy for stage II/III rectal cancer. Generalised estimating equations were used to adjust for education, living arrangements, area deprivation, comorbidity and clinical tumour characteristics. RESULTS: In colon cancer 92% of patients aged under 65 years, 77% of those aged 65 to 80 years and 27% of those aged over 80 years received adjuvant chemotherapy (χ2trends < 0.001). In rectal cancer preoperative radiotherapy was used in 68% of patients aged under 65 years, 60% of those aged 65 to 80 years, and 42% of those aged over 80 years (χ2trends < 0.001). Adjusting by comorbidity level, tumour characteristics and socioeconomic level, the odds ratio of use of chemotherapy compared with those under age 65, was 0.3 (0.1-0.6) and 0.04 (0.02-0.09) for those aged 65 to 80 and those aged over 80, respectively; similarly, the odds ratio of use of preoperative radiotherapy was 0.9 (0.6-1.4) and 0.5 (0.3-0.8) compared with those under 65 years of age. CONCLUSIONS: The probability of older patients with colorectal cancer receiving adjuvant chemotherapy and preoperative radiotherapy is lower than that of younger patients; many of them are not receiving the treatments recommended by clinical practice guidelines. Differences in comorbidity, tumour characteristics, curative resection, and socioeconomic factors do not explain this lower probability of treatment. Research is needed to identify the role of physical and cognitive functional status, doctors' attitudes, and preferences of patients and their relatives, in the use of adjuvant therapies.
Palabras clave
MESH
Age Factors | Aged | Aged, 80 and over | Chemotherapy, Adjuvant | Colectomy | Colonic Neoplasms | Comorbidity | Female | Humans | Male | Middle Aged | Neoadjuvant Therapy | Neoplasm Staging | Practice Guidelines as Topic | Proctectomy | Prospective Studies | Colorectal Neoplasms | Socioeconomic Factors
Versión en línea
DOI
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