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dc.contributor.authorCalvo, Cristina
dc.contributor.authorGarcía-García, María Luz
dc.contributor.authorPozo Sanchez, Francisco 
dc.contributor.authorPaula, Gallardo
dc.contributor.authorMolinero, Mar 
dc.contributor.authorCalderon-Reñon, Ana Maria 
dc.contributor.authorGonzález-Esguevillas, Mónica 
dc.contributor.authorCasas Flecha, Inmaculada 
dc.date.accessioned2020-04-21T08:40:00Z
dc.date.available2020-04-21T08:40:00Z
dc.date.issued2015-10
dc.identifier.citationMedicine (Baltimore) . 2015 Oct;94(42):e1788.es_ES
dc.identifier.issn0025-7974es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9642
dc.description.abstractIt is not clearly established if coinfections are more severe than single viral respiratory infections.The aim of the study was to study and to compare simple infections and viral coinfections of respiratory syncytial virus (RSV) in hospitalized children.From September 2005 to August 2013, a prospective study was conducted on children younger than 14 years of age, admitted with respiratory infection to the Pediatric Department of the Severo Ochoa Hospital, in Spain. Specimens of nasopharyngeal aspirate were taken for virological study by using polymerase chain reaction, and clinical data were recorded. Simple RSV infections were selected and compared with double infections of RSV with rhinovirus (RV) or with human bocavirus (HBoV).In this study, 2993 episodes corresponding to 2525 children were analyzed. At least 1 virus was detected in 77% (2312) of the episodes. Single infections (599 RSV, 513 RV, and 81 HBoV) were compared with 120 RSV-RV and 60 RSV-HBoV double infections. The RSV-RV coinfections had fever (63% vs 43%; P < 0.001) and hypoxia (70% vs 43%; P < 0.001) more often than RV infections. Hypoxia was similar between single or dual infections (71%). Bronchiolitis was more frequent in the RSV simple group (P < 0.001). Pediatric intensive care unit admission was more common in RSV simple or RSV-RV groups than in the RV monoinfection (P = 0.042).Hospitalization was longer for both RSV simple group and RSV-HBoV coinfection, lasting about 1 day (4.7 vs 3.8 days; P < 0.001) longer than in simple HBoV infections. There were no differences in PICU admission. RSV single group was of a younger age than the other groups.Coinfections between RSV-RV and RSV-HBoV are frequent. Overall viral coinfections do not present greater severity, but have mixed clinical features.es_ES
dc.description.sponsorshipThis study has been partially supported by FIS (Fondo de Investigaciones Sanitarias – Spanish Health Research Fund) Grants No.: PI06/0532, PI09/00246, and PI12/01291.es_ES
dc.language.isoenges_ES
dc.publisherLippincott Williams & Wilkins (LWW) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAdolescent es_ES
dc.subject.meshBronchiolitis es_ES
dc.subject.meshChild es_ES
dc.subject.meshCoinfection es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshNose es_ES
dc.subject.meshParvoviridae Infections es_ES
dc.subject.meshPicornaviridae Infections es_ES
dc.subject.meshProspective Studies es_ES
dc.subject.meshRespiratory Syncytial Virus Infections es_ES
dc.subject.meshHuman bocavirus es_ES
dc.subject.meshRhinovirus es_ES
dc.titleRespiratory Syncytial Virus Coinfections With Rhinovirus and Human Bocavirus in Hospitalized Childrenes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID26496310es_ES
dc.format.volume94es_ES
dc.format.number42es_ES
dc.format.pagee1788es_ES
dc.identifier.doi10.1097/MD.0000000000001788es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1536-5964es_ES
dc.relation.publisherversionhttps://doi.org/10.1097/MD.0000000000001788es_ES
dc.identifier.journalMedicinees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI06/0532es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI09/00246es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI12/01291es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución-NoComercial-CompartirIgual 4.0 Internacional