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dc.contributor.author | Casanova-Acebes, Maria | |
dc.contributor.author | Menendez-Gutierrez, Maria Piedad | |
dc.contributor.author | Porcuna, Jesus | |
dc.contributor.author | Alvarez-Errico, Damiana | |
dc.contributor.author | Lavin, Yonit | |
dc.contributor.author | Garcia, Ana | |
dc.contributor.author | Kobayashi, Soma | |
dc.contributor.author | Le Berichel, Jessica | |
dc.contributor.author | Nunez, Vanessa | |
dc.contributor.author | Were, Felipe | |
dc.contributor.author | Jimenez-Carretero, Daniel | |
dc.contributor.author | Sanchez-Cabo, Fatima | |
dc.contributor.author | Merad, Miriam | |
dc.contributor.author | Ricote, Mercedes | |
dc.date.accessioned | 2020-04-20T13:46:47Z | |
dc.date.available | 2020-04-20T13:46:47Z | |
dc.date.issued | 2020-04-03 | |
dc.identifier.citation | Nat Commun. 2020; 11(1):1655 | es_ES |
dc.identifier.issn | 2041-1723 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/9632 | |
dc.description.abstract | Tissue-resident macrophages (TRMs) populate all tissues and play key roles in homeostasis, immunity and repair. TRMs express a molecular program that is mostly shaped by tissue cues. However, TRM identity and the mechanisms that maintain TRMs in tissues remain poorly understood. We recently found that serous-cavity TRMs (LPMs) are highly enriched in RXR transcripts and RXR-response elements. Here, we show that RXRs control mouse serous-macrophage identity by regulating chromatin accessibility and the transcriptional regulation of canonical macrophage genes. RXR deficiency impairs neonatal expansion of the LPM pool and reduces the survival of adult LPMs through excess lipid accumulation. We also find that peritoneal LPMs infiltrate early ovarian tumours and that RXR deletion diminishes LPM accumulation in tumours and strongly reduces ovarian tumour progression in mice. Our study reveals that RXR signalling controls the maintenance of the serous macrophage pool and that targeting peritoneal LPMs may improve ovarian cancer outcomes. | es_ES |
dc.description.sponsorship | This work was supported by a HFSP fellowship to M.C-A. (LT000110/2015-L/1), grants from the Spanish Ministerio de Ciencia e Innovación (MCI) (SAF2015-64287R, SAF2017-90604-REDT-NurCaMein, RTI2018-095928-B100), La Marató de TV3 Foundation (201605-32) and Comunidad de Madrid (MOIR-B2017/BMD-3684) to M.R, and the Formación de Profesorado Universitario (FPU17/01731) programme (MCI) to J.P. The CNIC is supported by the MCI and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 32246014 | es_ES |
dc.format.volume | 11 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 1655 | es_ES |
dc.identifier.doi | 10.1038/s41467-020-15371-0 | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Fundación La Marató TV3 | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2041-1723 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s41467-020-15371-0 | es_ES |
dc.identifier.journal | Nature communications | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Señalización de los Receptores Nucleares | es_ES |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas::Bioinformática | es_ES |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas::Celómica | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2015-64287R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2017-90604-REDT-NurCaMein | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RTI2018-095928-B100 | es_ES |
dc.rights.accessRights | open access | es_ES |