Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/9632
Título
RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression
Autor(es)
Casanova-Acebes, Maria CNIC | Menendez-Gutierrez, Maria Piedad CNIC | Porcuna, Jesus CNIC | Alvarez-Errico, Damiana CNIC | Lavin, Yonit | Garcia, Ana CNIC | Kobayashi, Soma | Le Berichel, Jessica | Nunez, Vanessa CNIC | Were, Felipe CNIC | Jimenez-Carretero, Daniel CNIC | Sanchez-Cabo, Fatima CNIC | Merad, Miriam | Ricote, Mercedes CNIC
Fecha de publicación
2020-04-03
Cita
Nat Commun. 2020; 11(1):1655
Idioma
Inglés
Tipo de documento
journal article
Resumen
Tissue-resident macrophages (TRMs) populate all tissues and play key roles in homeostasis, immunity and repair. TRMs express a molecular program that is mostly shaped by tissue cues. However, TRM identity and the mechanisms that maintain TRMs in tissues remain poorly understood. We recently found that serous-cavity TRMs (LPMs) are highly enriched in RXR transcripts and RXR-response elements. Here, we show that RXRs control mouse serous-macrophage identity by regulating chromatin accessibility and the transcriptional regulation of canonical macrophage genes. RXR deficiency impairs neonatal expansion of the LPM pool and reduces the survival of adult LPMs through excess lipid accumulation. We also find that peritoneal LPMs infiltrate early ovarian tumours and that RXR deletion diminishes LPM accumulation in tumours and strongly reduces ovarian tumour progression in mice. Our study reveals that RXR signalling controls the maintenance of the serous macrophage pool and that targeting peritoneal LPMs may improve ovarian cancer outcomes.
Versión en línea
DOI
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- Nombre:
- RXRsControlSerousMacrophage_20 ...
- Tamaño:
- 86.66Kb
- Formato:
- Microsoft Excel 2007