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dc.contributor.author | Garcia-Broncano, Pilar | |
dc.contributor.author | Medrano, Luz Maria | |
dc.contributor.author | Berenguer, Juan | |
dc.contributor.author | González-García, Juan | |
dc.contributor.author | Jimenez-Sousa, Maria Angeles | |
dc.contributor.author | Carrero, Ana | |
dc.contributor.author | Hontañón, Victor | |
dc.contributor.author | Guardiola, Josep M | |
dc.contributor.author | Crespo, Manuel | |
dc.contributor.author | Quereda, Carmen | |
dc.contributor.author | Sanz, José | |
dc.contributor.author | Garcia-Gomez, Ana Belen | |
dc.contributor.author | Jimenez, Jose Luis | |
dc.contributor.author | Resino, Salvador | |
dc.date.accessioned | 2020-04-17T09:21:17Z | |
dc.date.available | 2020-04-17T09:21:17Z | |
dc.date.issued | 2018-11-02 | |
dc.identifier.citation | Cells. 2018 Nov 2;7(11). pii: E196. | es_ES |
dc.identifier.issn | 2073-4409 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/9594 | |
dc.description.abstract | BACKGROUND: Advanced cirrhosis is related to alterations in immunity. We aimed to evaluate the levels of peripheral CD4⁺ T cells (Tregs) and plasma cytokine in patients coinfected with human immunodeficiency virus and hepatitis C virus (HIV/HCV) according to liver fibrosis stages [evaluated as liver stiffness measure (LSM)] and their linear relationship. METHODS: We performed a cross-sectional study on 238 HIV/HCV-coinfected patients (119 had <12.5 kPa, 73 had 12.5⁻25 kPa, and 46 had >25 kPa). Peripheral T-cell subsets were phenotyped by flow cytometry, plasma biomarkers were assessed by multiplex immunoassays, and LSM was assessed by transient elastography. Results: We found HIV/HCV-coinfected patients had higher values of CD4⁺ Tregs (p < 0.001), memory Tregs (p ≤ 0.001), and plasma cytokine levels [IFN-γ (p ≤ 0.05) and IL-10 (p ≤ 0.01)] compared with healthy donors and HIV-monoinfected patients. In the multivariate analysis, higher LSM values were associated with reduced levels of IL-10 (adjusted arithmetic mean ratio (aAMR) = 0.83; p = 0.019), IL-2 (aAMR = 0.78; p = 0.017), TNF-α (aAMR = 0.67; p < 0.001), and IL-17A (aAMR = 0.75; p = 0.006). When we focus on HIV/HCV-coinfected patients analyzed by LSM strata, patients with ≥25 kPa had lower values of IL-2 (aAMR = 0.66; p = 0.021), TNF-α (aAMR = 0.565; p = 0.003), and IL-17A (aAMR = 0.58; p = 0.003) than patients with <12.5 kPa. CONCLUSION: HIV/HCV-coinfected patients showed an immunosuppressive profile compared to healthy controls and HIV-monoinfected patients. Additionally, HIV/HCV-coinfected patients with advanced cirrhosis (LSM ≥ 25 kPa) had the lowest plasma values of cytokines related to Th1 (IL-2 and TNF-α) and Th17 (IL-17A) response. | es_ES |
dc.description.sponsorship | This study was supported by grants from Instituto de Salud Carlos III (ISCII; grant numbers grant numbers PI14/01094 and PI17/00657 to JB, PI14/01581 and PI17/00903 to JGG, PI14CIII/00011 and PI17CIII/00003 to SR, and PI17/01115 to JLJ), Ministerio de Sanidad, Servicios Sociales e Igualdad (grant number EC11-241), Comunidad de Madrid (B2017/BMD3703). The study was also funded by the RD16CIII/0002/0002, RD16/0025/0018, and RD16/0025/0017 projects as part of the Plan Nacional R + D + I and co-funded by ISCIII- Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER). J.B. is an investigator from the Programa de Intensificación de la Actividad Investigadora en el Sistema Nacional de Salud (I3SNS), Refs INT15/00079 and INT16/00100. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | HIV | es_ES |
dc.subject | Treg cells | es_ES |
dc.subject | Chronic hepatitis C | es_ES |
dc.subject | Cirrhosis | es_ES |
dc.subject | Cytokines | es_ES |
dc.subject | Immune dysfunction | es_ES |
dc.title | Dysregulation of the Immune System in HIV/HCV-Coinfected Patients According to Liver Stiffness Status | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 30400258 | es_ES |
dc.format.volume | 7 | es_ES |
dc.format.number | 11 | es_ES |
dc.format.page | 196 | es_ES |
dc.identifier.doi | 10.3390/cells7110196 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Ministerio de Sanidad, Servicios Sociales e Igualdad (España) | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/cells7110196 | es_ES |
dc.identifier.journal | Cells | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/PI14/01094 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/PI17/00657 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/PI14/01581 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/PI17/00903 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/PI14CIII/00011 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/PI17CIII/00003 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/PI17/01115 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/EC11-241 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/B2017/BMD3703 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/RD16CIII/0002/0002 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/RD16/0025/0018 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/RD16/0025/0017 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/INT15/00079 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/INT16/00100 | es_ES |
dc.rights.accessRights | open access | es_ES |