Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/9495
Effect of Early Metoprolol During ST-Segment Elevation Myocardial Infarction on Left Ventricular Strain: Feature-Tracking Cardiovascular Magnetic Resonance Substudy From the METOCARD-CNIC Trial
Podlesnikar, Tomaž | Pizarro, Gonzalo CNIC | Fernandez-Jimenez, Rodrigo CNIC | Montero-Cabezas, Jose M | Sanchez-Gonzalez, Javier CNIC | Bucciarelli-Ducci, Chiara | Ajmone Marsan, Nina | Fras, Zlatko | Bax, Jeroen J | Fuster, Valentin CNIC | Ibanez, Borja CNIC | Delgado, Victoria
JACC Cardiovasc Imaging. 2019; 12(7 Pt 1):1188-1198
OBJECTIVES: This study sought to evaluate the effect of early intravenous metoprolol on left ventricular (LV) strain assessed with feature-tracking cardiovascular magnetic resonance (CMR). BACKGROUND: Early intravenous metoprolol before primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) portends better outcomes in the METOCARD-CNIC (Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction) trial. METHODS: A total of 197 patients with acute anterior STEMI who were enrolled in the METOCARD-CNIC trial (100 allocated to intravenous metoprolol before primary PCI and 97 control patients) were evaluated. LV global circumferential strain (GCS) and global longitudinal strain (GLS) were measured with feature-tracking CMR at 1 week and 6 months after STEMI and compared between randomization groups. RESULTS: Patients who received early intravenous metoprolol had significantly more preserved LV strain compared with the control patients at 1 week after STEMI (GCS -13.9 ± 3.8% vs. -12.6 ± 3.9%, respectively; p = 0.013; GLS -11.9 ± 2.8% vs. -10.9 ± 3.2%, respectively; p = 0.032). In both groups, LV strain significantly improved during follow-up (mean difference between 6-month and 1-week strain for the metoprolol group: GCS -2.9%, 95% confidence interval [CI]: -3.5% to -2.4%; GLS: -2.9%, 95% CI: -3.4% to -2.4%; both p < 0.001; the control group: GCS -3.4%, 95% CI: -3.9% to -2.8%; GLS -3.4%, 95% CI: -3.9% to -3.0%; both p < 0.001). When dividing the overall cohort of patients in quartiles of GCS and GLS, there were significantly fewer patients in the first quartile (i.e., the worst LV systolic function) who received early intravenous metoprolol compared with control patients at 1 week and 6 months (p < 0.05 for GCS and GLS at both time points). CONCLUSIONS: In patients with anterior STEMI, early administration of intravenous metoprolol before primary PCI was associated with significantly fewer patients with severely depressed LV GCS and GLS, both at 1 week and 6 months. Feature-tracking CMR represents a complementary tool to evaluate the benefits of cardioprotective therapies. (Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion [METOCARD-CNIC]: NCT01311700).
ST-segment elevation myocardial infarction | Cardiovascular magnetic resonance | Feature-tracking | Global circumferential strain | Global longitudinal strain | Intravenous metoprolol
Administration, Intravenous | Adrenergic beta-1 Receptor Antagonists | Aged | Drug Administration Schedule | Europe | Female | Humans | Male | Metoprolol | Middle Aged | Observer Variation | Predictive Value of Tests | Reproducibility of Results | ST Elevation Myocardial Infarction | Time Factors | Treatment Outcome | Ventricular Function, Left | Magnetic Resonance Imaging, Cine | Percutaneous Coronary Intervention
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