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dc.contributor.authorPodlesnikar, Tomaž
dc.contributor.authorPizarro, Gonzalo 
dc.contributor.authorFernandez-Jimenez, Rodrigo 
dc.contributor.authorMontero-Cabezas, Jose M
dc.contributor.authorSanchez-Gonzalez, Javier 
dc.contributor.authorBucciarelli-Ducci, Chiara
dc.contributor.authorAjmone Marsan, Nina
dc.contributor.authorFras, Zlatko
dc.contributor.authorBax, Jeroen J
dc.contributor.authorFuster, Valentin 
dc.contributor.authorIbanez, Borja 
dc.contributor.authorDelgado, Victoria
dc.identifier.citationJACC Cardiovasc Imaging. 2019; 12(7 Pt 1):1188-1198es_ES
dc.description.abstractOBJECTIVES: This study sought to evaluate the effect of early intravenous metoprolol on left ventricular (LV) strain assessed with feature-tracking cardiovascular magnetic resonance (CMR). BACKGROUND: Early intravenous metoprolol before primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) portends better outcomes in the METOCARD-CNIC (Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction) trial. METHODS: A total of 197 patients with acute anterior STEMI who were enrolled in the METOCARD-CNIC trial (100 allocated to intravenous metoprolol before primary PCI and 97 control patients) were evaluated. LV global circumferential strain (GCS) and global longitudinal strain (GLS) were measured with feature-tracking CMR at 1 week and 6 months after STEMI and compared between randomization groups. RESULTS: Patients who received early intravenous metoprolol had significantly more preserved LV strain compared with the control patients at 1 week after STEMI (GCS -13.9 ± 3.8% vs. -12.6 ± 3.9%, respectively; p = 0.013; GLS -11.9 ± 2.8% vs. -10.9 ± 3.2%, respectively; p = 0.032). In both groups, LV strain significantly improved during follow-up (mean difference between 6-month and 1-week strain for the metoprolol group: GCS -2.9%, 95% confidence interval [CI]: -3.5% to -2.4%; GLS: -2.9%, 95% CI: -3.4% to -2.4%; both p < 0.001; the control group: GCS -3.4%, 95% CI: -3.9% to -2.8%; GLS -3.4%, 95% CI: -3.9% to -3.0%; both p < 0.001). When dividing the overall cohort of patients in quartiles of GCS and GLS, there were significantly fewer patients in the first quartile (i.e., the worst LV systolic function) who received early intravenous metoprolol compared with control patients at 1 week and 6 months (p < 0.05 for GCS and GLS at both time points). CONCLUSIONS: In patients with anterior STEMI, early administration of intravenous metoprolol before primary PCI was associated with significantly fewer patients with severely depressed LV GCS and GLS, both at 1 week and 6 months. Feature-tracking CMR represents a complementary tool to evaluate the benefits of cardioprotective therapies. (Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion [METOCARD-CNIC]: NCT01311700).es_ES
dc.description.sponsorshipThe METOCARD-CNIC trial was partially supported by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), through CNIC Translational Grant 01-2009. Other sponsors were the Spanish Ministry of Health and Social Policy (EC10-042), the Mutua Madrileña Foundation (AP8695-2011), and a Master Research Agreement between Philips Healthcare and the CNIC. Dr. Ibáñez is supported in part by the ISCIII Fondo de Investigación Sanitaria grants and ERDF/FEDER funds PI16/02110, DTS17/00136, PI13/01979, and SAF2015-71613-REDI. The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades (MICINN) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). Dr. Bucciarelli-Ducci is supported by the Bristol National Institute of Health Research (NIHR) Biomedical Research Centre (BRC). The views expressed are those of the authors and not necessarily those of the National Health Service, National Institute for Health Research or Department of Health. Dr. Sánchez-González is a Philips Healthcare employee. Dr. Bucciarelli-Ducci has been a consultant for Circle Cardiovascular Imaging. Dr. Delgado has received speaker fees from Abbott Vascular; and research grants to the Department of Cardiology of the Leiden University Medical Center from Biotronik, Medtronic, Boston Scientific, and Edwards Lifesciences.es_ES
dc.publisherElsevier es_ES
dc.subjectST-segment elevation myocardial infarctiones_ES
dc.subjectCardiovascular magnetic resonancees_ES
dc.subjectGlobal circumferential straines_ES
dc.subjectGlobal longitudinal straines_ES
dc.subjectIntravenous metoprololes_ES
dc.subject.meshAdministration, Intravenous es_ES
dc.subject.meshAdrenergic beta-1 Receptor Antagonists es_ES
dc.subject.meshAged es_ES
dc.subject.meshDrug Administration Schedule es_ES
dc.subject.meshEurope es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshMetoprolol es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshObserver Variation es_ES
dc.subject.meshPredictive Value of Tests es_ES
dc.subject.meshReproducibility of Results es_ES
dc.subject.meshST Elevation Myocardial Infarction es_ES
dc.subject.meshTime Factors es_ES
dc.subject.meshTreatment Outcome es_ES
dc.subject.meshVentricular Function, Left es_ES
dc.subject.meshMagnetic Resonance Imaging, Cine es_ES
dc.subject.meshPercutaneous Coronary Intervention es_ES
dc.titleEffect of Early Metoprolol During ST-Segment Elevation Myocardial Infarction on Left Ventricular Strain: Feature-Tracking Cardiovascular Magnetic Resonance Substudy From the METOCARD-CNIC Triales_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.format.number7 Pt 1es_ES
dc.contributor.funderCentro Nacional de Investigaciones Cardiovasculares Carlos III (España) 
dc.contributor.funderMinisterio de Sanidad y Política Social (España) 
dc.contributor.funderFundación Mutua Madrileña 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España) 
dc.contributor.funderFundación ProCNIC 
dc.contributor.funderNational Institutes of Health (Estados Unidos) 
dc.identifier.journalJACC. Cardiovascular imaginges_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.rights.accessRightsembargoed accesses_ES

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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