dc.contributor.author | Grazioso, Tatiana P | |
dc.contributor.author | Brandt, Marta | |
dc.contributor.author | Djouder, Nabil | |
dc.date.accessioned | 2020-03-30T15:10:26Z | |
dc.date.available | 2020-03-30T15:10:26Z | |
dc.date.issued | 2019-11-22 | |
dc.identifier.citation | iScience. 2019 ;21:168-187. | es_ES |
dc.identifier.issn | 25890042 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/9373 | |
dc.description.abstract | The intestinal epithelium is a very dynamic tissue under a high regenerative pressure, which makes it susceptible to malignant transformation. Proper integration of various cell signaling pathways and a balanced cross talk between different cell types composing the organ are required to maintain intestinal homeostasis. Dysregulation of this balance can lead to colorectal cancer (CRC). Here, we review important insights into molecular and cellular mechanisms of CRC. We discuss how perturbation in complex regulatory networks, including the Wnt, Notch, BMP, and Hedgehog pathways; and how variations in inflammatory signaling, nutrients, and microbiota can affect intestinal homeostasis contributing to the malignant transformation of intestinal cells. | es_ES |
dc.description.sponsorship | This work was supported by the SpanishMinistry of Science, Innovation and Universities, and co-funded by ERDF-EU (FEDER, SAF2016-76598-R). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Biological Sciences | es_ES |
dc.subject | Cancer | es_ES |
dc.subject | Microbiome | es_ES |
dc.title | Diet, Microbiota, and Colorectal Cancer | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 31669832 | es_ES |
dc.format.volume | 21 | es_ES |
dc.format.page | 168-187 | es_ES |
dc.identifier.doi | 10.1016/j.isci.2019.10.011 | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2589-0042 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.isci.2019.10.011 | es_ES |
dc.identifier.journal | iScience | es_ES |
dc.repisalud.institucion | CNIO | es_ES |
dc.repisalud.orgCNIO | CNIO::Grupos de investigación::Grupo de Factores de Crecimiento, Nutrientes y Cáncer | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/SAF2016-76598-R | es_ES |
dc.rights.accessRights | open access | es_ES |