Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/9373
Título
Diet, Microbiota, and Colorectal Cancer
Autor(es)
Fecha de publicación
2019-11-22
Cita
iScience. 2019 ;21:168-187.
Idioma
Inglés
Tipo de documento
journal article
Resumen
The intestinal epithelium is a very dynamic tissue under a high regenerative pressure, which makes it susceptible to malignant transformation. Proper integration of various cell signaling pathways and a balanced cross talk between different cell types composing the organ are required to maintain intestinal homeostasis. Dysregulation of this balance can lead to colorectal cancer (CRC). Here, we review important insights into molecular and cellular mechanisms of CRC. We discuss how perturbation in complex regulatory networks, including the Wnt, Notch, BMP, and Hedgehog pathways; and how variations in inflammatory signaling, nutrients, and microbiota can affect intestinal homeostasis contributing to the malignant transformation of intestinal cells.
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Versión en línea
DOI
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