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dc.contributor.authorGrazioso, Tatiana P
dc.contributor.authorBrandt, Marta
dc.contributor.authorDjouder, Nabil 
dc.date.accessioned2020-03-30T15:10:26Z
dc.date.available2020-03-30T15:10:26Z
dc.date.issued2019-11-22
dc.identifier.citationiScience. 2019 ;21:168-187.es_ES
dc.identifier.issn25890042es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9373
dc.description.abstractThe intestinal epithelium is a very dynamic tissue under a high regenerative pressure, which makes it susceptible to malignant transformation. Proper integration of various cell signaling pathways and a balanced cross talk between different cell types composing the organ are required to maintain intestinal homeostasis. Dysregulation of this balance can lead to colorectal cancer (CRC). Here, we review important insights into molecular and cellular mechanisms of CRC. We discuss how perturbation in complex regulatory networks, including the Wnt, Notch, BMP, and Hedgehog pathways; and how variations in inflammatory signaling, nutrients, and microbiota can affect intestinal homeostasis contributing to the malignant transformation of intestinal cells.es_ES
dc.description.sponsorshipThis work was supported by the SpanishMinistry of Science, Innovation and Universities, and co-funded by ERDF-EU (FEDER, SAF2016-76598-R).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBiological Scienceses_ES
dc.subjectCanceres_ES
dc.subjectMicrobiomees_ES
dc.titleDiet, Microbiota, and Colorectal Canceres_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID31669832es_ES
dc.format.volume21es_ES
dc.format.page168-187es_ES
dc.identifier.doi10.1016/j.isci.2019.10.011es_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)
dc.description.peerreviewedes_ES
dc.identifier.e-issn2589-0042es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.isci.2019.10.011es_ES
dc.identifier.journaliSciencees_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Factores de Crecimiento, Nutrientes y Cánceres_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/SAF2016-76598-Res_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
This item is licensed under a: Atribución-NoComercial-CompartirIgual 4.0 Internacional