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dc.contributor.author | Santos-Lozano, Alejandro | |
dc.contributor.author | Valenzuela, Pedro L | |
dc.contributor.author | Llavero, Francisco | |
dc.contributor.author | Lista, Simone | |
dc.contributor.author | Carrera-Bastos, Pedro | |
dc.contributor.author | Hampel, Harald | |
dc.contributor.author | Pareja-Galeano, Helios | |
dc.contributor.author | Gálvez, Beatriz G | |
dc.contributor.author | Lopez, Juan Antonio | |
dc.contributor.author | Vazquez, Jesus | |
dc.contributor.author | Emanuele, Enzo | |
dc.contributor.author | Zugaza, José L | |
dc.contributor.author | Lucia, Alejandro | |
dc.date.accessioned | 2020-03-09T13:48:34Z | |
dc.date.available | 2020-03-09T13:48:34Z | |
dc.date.issued | 2020-02 | |
dc.identifier.citation | Aging (Albany NY). 2020; 12(4):3502-3515 | es_ES |
dc.identifier.issn | 1945-4589 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/9247 | |
dc.description.abstract | Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and related to enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging. | es_ES |
dc.description.sponsorship | The work of PLV is supported by University of Alcalá (FPI2016). AL and JLZ are supported by grants from the Spanish Ministry of Science, Innovation and Universities and Fondos FEDER (Fondo de Investigaciones Sanitarias [FIS], grants number PI15/00558, PI18/00139, and PI18/00207). JV and JAL are supported by grants from MINECO (BIO2015-67580-P), the Fundació Marató TV3 (122/C/2015) and “la Caixa” Banking Foundation (project code HR17-00247). The CNIC is supported by the Spanish Ministry of Economy and Science, Innovation and Universities and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). HH is an employee of Eisai Inc. During his previous work (until April 2019) he was supported by the AXA Research Fund, the “Fondation partenariale Sorbonne Université” and the “Fondation pour la Recherche sur Alzheimer”, Paris, France. HP is suppoted by grant from Universidad Europea de Madrid (#2017/UEM05). | es_ES |
dc.language.iso | eng | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Elderly | es_ES |
dc.subject | Healthy aging | es_ES |
dc.subject | Immune system | es_ES |
dc.subject | Proteomics | es_ES |
dc.subject | Senescence | es_ES |
dc.title | Successful aging: insights from proteome analyses of healthy centenarians | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 32100723 | es_ES |
dc.format.volume | 12 | es_ES |
dc.format.number | 4 | es_ES |
dc.format.page | 3502-3515 | es_ES |
dc.identifier.doi | 10.18632/aging.102826 | es_ES |
dc.contributor.funder | University of Alcalá (España) | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Fundación La Marató TV3 | |
dc.contributor.funder | Fundación La Caixa | |
dc.contributor.funder | Fundación ProCNIC | |
dc.contributor.funder | Fundación AXA | |
dc.contributor.funder | Fundación de la Universidad Europea de Madrid | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1945-4589 | es_ES |
dc.relation.publisherversion | https://doi.org/10.18632/aging.102826 | es_ES |
dc.identifier.journal | Aging | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Proteómica cardiovascular | es_ES |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas::Proteómica / Metabolómica | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/00558 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI18/00139 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI18/00207 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/BIO2015-67580-P | es_ES |
dc.rights.accessRights | open access | es_ES |