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dc.contributor.authorSantos-Lozano, Alejandro
dc.contributor.authorValenzuela, Pedro L
dc.contributor.authorLlavero, Francisco
dc.contributor.authorLista, Simone
dc.contributor.authorCarrera-Bastos, Pedro
dc.contributor.authorHampel, Harald
dc.contributor.authorPareja-Galeano, Helios
dc.contributor.authorGálvez, Beatriz G
dc.contributor.authorLopez, Juan Antonio 
dc.contributor.authorVazquez, Jesus 
dc.contributor.authorEmanuele, Enzo
dc.contributor.authorZugaza, José L
dc.contributor.authorLucia, Alejandro
dc.date.accessioned2020-03-09T13:48:34Z
dc.date.available2020-03-09T13:48:34Z
dc.date.issued2020-02
dc.identifier.citationAging (Albany NY). 2020; 12(4):3502-3515es_ES
dc.identifier.issn1945-4589es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9247
dc.description.abstractHealthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and related to enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging.es_ES
dc.description.sponsorshipThe work of PLV is supported by University of Alcalá (FPI2016). AL and JLZ are supported by grants from the Spanish Ministry of Science, Innovation and Universities and Fondos FEDER (Fondo de Investigaciones Sanitarias [FIS], grants number PI15/00558, PI18/00139, and PI18/00207). JV and JAL are supported by grants from MINECO (BIO2015-67580-P), the Fundació Marató TV3 (122/C/2015) and “la Caixa” Banking Foundation (project code HR17-00247). The CNIC is supported by the Spanish Ministry of Economy and Science, Innovation and Universities and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). HH is an employee of Eisai Inc. During his previous work (until April 2019) he was supported by the AXA Research Fund, the “Fondation partenariale Sorbonne Université” and the “Fondation pour la Recherche sur Alzheimer”, Paris, France. HP is suppoted by grant from Universidad Europea de Madrid (#2017/UEM05).es_ES
dc.language.isoenges_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectelderlyes_ES
dc.subjecthealthy aginges_ES
dc.subjectimmune systemes_ES
dc.subjectproteomicses_ES
dc.subjectsenescencees_ES
dc.titleSuccessful aging: insights from proteome analyses of healthy centenarianses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID32100723es_ES
dc.format.volume12es_ES
dc.format.number4es_ES
dc.format.page3502-3515es_ES
dc.identifier.doi10.18632/aging.102826es_ES
dc.contributor.funderUniversidad de Alcaláes_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderFundacio La Maratoes_ES
dc.contributor.funderFundación La Caixaes_ES
dc.contributor.funderFundación ProCNICes_ES
dc.contributor.funderAXA Resarch Fundes_ES
dc.contributor.funderUniversidad Europea de Madrides_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1945-4589es_ES
dc.relation.publisherversionhttps://doi.org/10.18632/aging.102826es_ES
dc.identifier.journalAginges_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Proteómica cardiovasculares_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Proteómica / Metabolómicaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/00558es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI18/00139es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI18/00207es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BIO2015-67580-Pes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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