Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/9070
Título
Impact of DARC rs12075 Variants on Liver Fibrosis Progression in Patients with Chronic Hepatitis C: A Retrospective Study
Autor(es)
Jimenez-Sousa, Maria Angeles ISCIII | Gómez-Moreno, Ana Zaida | Pineda-Tenor, Daniel ISCIII | Sánchez-Ruano, Juan José | Artaza-Varasa, Tomas | Martin-Vicente, Maria ISCIII | Fernandez-Rodriguez, Amanda ISCIII | Martinez, Isidoro ISCIII | Resino, Salvador ISCIII
Fecha de publicación
2019
Cita
Biomolecules. 2019 Apr 9;9(4). pii: E143.
Idioma
Inglés
Tipo de documento
journal article
Resumen
The Duffy antigen receptor for chemokines (DARC) rs12075 polymorphism regulates leukocyte trafficking and proinflammatory chemokine homeostasis. Hepatitis C virus (HCV)-mediated liver fibrosis is associated with an uncontrolled inflammatory response. In this study, we evaluate the association between the DARC rs12075 polymorphism and liver stiffness progression in HCV-infected patients. We carried out a retrospective cohort study (repeated measures design) in 208 noncirrhotic patients with chronic hepatitis C (CHC) who had at least two liver stiffness measurements (LSM) with a separation of at least 12 months. We used generalized linear models to analyze the association between DARC rs12075 polymorphism and outcome variables. During a follow-up of 46.6 months, the percentage of patients with stages of fibrosis F0/F1 decreased (p < 0.001), while LSM values and the percentage of patients with cirrhosis increased (p < 0.001). This pattern of changes was maintained in each of the groups of patients analyzed according to their rs12075 genotypes (AA or AG/GG). However, the variations in liver stiffness characteristics were lower in patients with the rs12075 AG/GG genotype (AG/GG versus AA). Thereby, in the adjusted analysis, patients with the rs12075 AG/GG genotype had a lower risk of an increased value of LSM2/LSM1 arithmetic mean ratio (AMR = 0.83; p = 0.001) and of an increase in LSM ≥ 5 kPa (odds ratio (OR) = 0.28; p = 0.009). Besides, patients with rs12075 AG/GG had a lower risk of cirrhosis progression (OR = 0.24; p = 0.009). No significant associations were found for an increase in LSM ≥ 10 kPa. We found an association between the DARC rs12075 single nucleotide polymorphism (SNP) and CHC progression. Specifically, patients with the DARC rs12075 AG/GG genotype had a lower risk of liver fibrosis progression and development of cirrhosis.
Palabras clave
DARC | Chronic hepatitis C | Cirrhosis | Hepatic fibrosis | Liver stiffness | Single nucleotide polymorphisms
MESH
Adult | Duffy Blood-Group System | Female | Hepatitis C, Chronic | Humans | Liver | Liver Cirrhosis | Male | Middle Aged | Receptors, Cell Surface | Polymorphism, Single Nucleotide
Versión en línea
DOI
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