Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/9003
Título
Increase of pertussis incidence in 2010 to 2012 after 12 years of low circulation in Spain
Autor(es)
Sizaire, Vinciane ISCIII | Garrido-Estepa, Macarena ISCIII | Masa-Calles, Josefa ISCIII | Martinez de Aragon-Esquivias, Maria Victoria ISCIII
Fecha de publicación
2014-08-14
Cita
Euro Surveill. 2014 Aug 14;19(32). pii: 20875.
Idioma
Inglés
Tipo de documento
journal article
Resumen
In Spain, whole cell pertussis vaccination started in 1975, with three doses before the age of 6-7 months. Doses at 15-18 months and 4-6 years were introduced in 1996 and 2001, respectively. Spain switched to an acellular vaccine in 2005. From 1998 to 2009, pertussis incidence rates remained ≤1.5 cases/100,000 inhabitants but increased from 2010 to 7.5 cases/100,000 in 2012. Data from 1998 to 2012 were analysed to assess disease trends and susceptible populations. We defined four epidemic periods: 1998-2001 (reference), 2002-05, 2006-09 and 2010-12. In 2002-05, the incidence rate increased in individuals aged 15-49 years (IRR: 1.41 (95% CI: 1.11-1.78)) and ≥50 years (IRR: 2.78 (95% CI: 1.78-4.33)) and in 2006-09 increased also in infants aged <3 months (IRR: 1.83 (95% CI: 1.60-2.09)). In 2010-12, the incidence rate increased notably in all age groups, with IRRs ranging between 2.5 (95% CI: 2.3-2.8) in 5-9 year-olds and 36.0 (95% CI: 19.4-66.8) in 20-29 year-olds. These results, consistent with the country's vaccination history, suggest a progressive accumulation of susceptible individuals due to waning immunity after years of low incidence. Further vaccination strategies should be assessed and implemented to prevent pertussis in pre-vaccinated infants, in whom the disease is more severe.
MESH
Adolescent | Adult | Age Distribution | Bordetella pertussis | Child | Child, Preschool | Epidemics | Female | Hospitalization | Humans | Immunization Programs | Incidence | Infant | Infant, Newborn | Male | Middle Aged | Pertussis Vaccine | Population Surveillance | Spain | Time Factors | Whooping Cough | Young Adult
Versión en línea
DOI
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