Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/8971
The Application and Interpretation of IgG Avidity and IgA ELISA Tests to Characterize Zika Virus Infections
Amaro, Fatima ISCIII | Sanchez-Seco, Paz ISCIII | Vazquez, Ana ISCIII | Alves, Maria J | Zé-Zé, Líbia | Luz, Maria T ISCIII | Minguito, Teodora ISCIII | Fuente, Jesus de la ISCIII | De Ory, Fernando de ISCIII
Viruses. 2019 Feb 20;11(2). pii: E179.
In the absence of viremia, the diagnostics of Zika virus (ZIKV) infections must rely on serological techniques. In order to improve the serological diagnosis of ZIKV, ZIKV-IgA and ZIKV-IgG avidity assays were evaluated. Forty patients returning from ZIKV endemic areas, with confirmed or suspected ZIKV infections were studied. Samples were classified as early acute, acute and late acute according to the number of days post illness onset. Low avidity IgG was only detected at acute and late acute stages and IgA mostly at the early acute and acute stages. The date of sampling provides useful information and can help to choose the best technique to use at a determined moment in time and to interpret low avidity IgG and IgA results, improving the serological diagnosis of ZIKV.
Cross Reactions | Data Interpretation, Statistical | Disease Outbreaks | Humans | Immunoglobulin A | Immunoglobulin G | Sensitivity and Specificity | Zika Virus | Zika Virus Infection | Antibody Affinity | Enzyme-Linked Immunosorbent Assay
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