Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/8936
Título
An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation
Autor(es)
Echarri, Asier CNIC | Pavon, Dacil Maria CNIC | Sanchez, Sara CNIC | Garcia-Garcia, Maria CNIC | Calvo, Enrique CNIC | Huerta-Lopez, Carla CNIC | Velazquez-Carreras, Diana CNIC | Viaris de Lesegno, Christine | Ariotti, Nicholas | Lázaro-Carrillo, Ana | Strippoli, Raffaele CNIC | De Sancho, David | Alegre-Cebollada, Jorge CNIC | Lamaze, Christophe | Parton, Robert G | del Pozo, Miguel Angel CNIC
Fecha de publicación
2019-12-20
Cita
Nat Commun. 2019; 10(1):5828
Idioma
Inglés
Tipo de documento
journal article
Resumen
Cells remodel their structure in response to mechanical strain. However, how mechanical forces are translated into biochemical signals that coordinate the structural changes observed at the plasma membrane (PM) and the underlying cytoskeleton during mechanoadaptation is unclear. Here, we show that PM mechanoadaptation is controlled by a tension-sensing pathway composed of c-Abl tyrosine kinase and membrane curvature regulator FBP17. FBP17 is recruited to caveolae to induce the formation of caveolar rosettes. FBP17 deficient cells have reduced rosette density, lack PM tension buffering capacity under osmotic shock, and cannot adapt to mechanical strain. Mechanistically, tension is transduced to the FBP17 F-BAR domain by direct phosphorylation mediated by c-Abl, a mechanosensitive molecule. This modification inhibits FBP17 membrane bending activity and releases FBP17-controlled inhibition of mDia1-dependent stress fibers, favoring membrane adaptation to increased tension. This mechanoprotective mechanism adapts the cell to changes in mechanical tension by coupling PM and actin cytoskeleton remodeling.
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