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dc.contributor.authorVela, Maria
dc.contributor.authorDel Rosal, Teresa
dc.contributor.authorPérez-Martínez, Antonio
dc.contributor.authorValentín, Jaime
dc.contributor.authorCasas Flecha, Inmaculada 
dc.contributor.authorPozo Sanchez, Francisco 
dc.contributor.authorReinoso-Barbero, Francisco
dc.contributor.authorBueno, David
dc.contributor.authorCorral, Dolores
dc.contributor.authorMéndez-Echevarría, Ana
dc.contributor.authorMozo, Yasmina
dc.contributor.authorCalvo, Cristina
dc.date.accessioned2019-12-20T11:48:56Z
dc.date.available2019-12-20T11:48:56Z
dc.date.issued2019-12-11
dc.identifier.citationSci Rep. 2019 Dec 11;9(1):18792.es_ES
dc.identifier.issn2045-2322es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8849
dc.description.abstractInfection is the leading cause of non-relapse-related mortality after allogeneic haematopoietic stem cell transplantation (HSCT). Altered functions of immune cells in nasal secretions may influence post HSCT susceptibility to viral respiratory infections. In this prospective study, we determined T and NK cell numbers together with NK activation status in nasopharyngeal aspirates (NPA) in HSCT recipients and healthy controls using multiparametric flow cytometry. We also determined by polymerase chain reaction (PCR) the presence of 16 respiratory viruses. Samples were collected pre-HSCT, at day 0, +10, +20 and +30 after HSCT. Peripheral blood (PB) was also analyzed to determine T and NK cell numbers. A total of 27 pediatric HSCT recipients were enrolled and 16 of them had at least one viral detection (60%). Rhinovirus was the most frequent pathogen (84% of positive NPAs). NPAs of patients contained fewer T and NK cells compared to healthy controls (p = 0.0132 and p = 0.120, respectively). Viral PCR + patients showed higher NK cell number in their NPAs. The activating receptors repertoire expressed by NK cells was also higher in NPA samples, especially NKp44 and NKp46. Our study supports NK cells relevance for the immune defense against respiratory viruses in HSCT recipients.es_ES
dc.description.sponsorshipThis work was supported in part by the National Health Service of Spain, Instituto de Salud Carlos III (ISCIII), FONDOS FEDER grant (FIS) PI18/01301, CRIS Foundation to Beat Cancer, Patients’ Support Associations Fundación Mari Paz Jiménez Casado and La Sonrisa de Álex and a Small Grant Award from the European Society for Paediatric Infectious Diseases.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Group es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titlePossible role of highly activated mucosal NK cells against viral respiratory infections in children undergoing haematopoietic stem cell transplantationes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID31827202es_ES
dc.format.volume9es_ES
dc.format.number1es_ES
dc.format.page18792es_ES
dc.identifier.doi10.1038/s41598-019-55398-yes_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn2045-2322es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-019-55398-yes_ES
dc.identifier.journalScientific reportses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiología::Área de Virología::Unidad de Virus Respiratorios y Gripees_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/(FIS) PI18/01301es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
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