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dc.contributor.authorCoronel Lopez, Raquel 
dc.contributor.authorPalmer, Charlotte 
dc.contributor.authorBernabeu-Zornoza, Adela 
dc.contributor.authorMonteagudo, Maria 
dc.contributor.authorRosca, Andreea 
dc.contributor.authorZambrano, Alberto 
dc.contributor.authorListe-Noya, Isabel 
dc.date.accessioned2019-12-11T10:03:40Z
dc.date.available2019-12-11T10:03:40Z
dc.date.issued2019-10
dc.identifier.citationNeural Regen Res. 2019 Oct;14(10):1661-1671.es_ES
dc.identifier.issn1673-5374es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8806
dc.description.abstractThe pathological implication of amyloid precursor protein (APP) in Alzheimer's disease has been widely documented due to its involvement in the generation of amyloid-β peptide. However, the physiological functions of APP are still poorly understood. APP is considered a multimodal protein due to its role in a wide variety of processes, both in the embryo and in the adult brain. Specifically, APP seems to play a key role in the proliferation, differentiation and maturation of neural stem cells. In addition, APP can be processed through two canonical processing pathways, generating different functionally active fragments: soluble APP-α, soluble APP-β, amyloid-β peptide and the APP intracellular C-terminal domain. These fragments also appear to modulate various functions in neural stem cells, including the processes of proliferation, neurogenesis, gliogenesis or cell death. However, the molecular mechanisms involved in these effects are still unclear. In this review, we summarize the physiological functions of APP and its main proteolytic derivatives in neural stem cells, as well as the possible signaling pathways that could be implicated in these effects. The knowledge of these functions and signaling pathways involved in the onset or during the development of Alzheimer's disease is essential to advance the understanding of the pathogenesis of Alzheimer's disease, and in the search for potential therapeutic targets.es_ES
dc.description.sponsorshipFinancial support: This work was supported by grants from the Ministerio de Ciencia e Innovación-Instituto de Salud Carlos III (PI-10/00291 and MPY1412/09), Ministerio de Economía y Competitividad (SAF2015-71140-R) and Comunidad de Madrid (Neurostem-Comunidad de Madrid consortium; S2010/BMD-2336). RC was supported by grants from Plan de Empleo Juvenil-Ministerio de Economía y Competitividad.es_ES
dc.language.isoenges_ES
dc.publisherMedknow Publications es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAPPes_ES
dc.subjectAPP intracellular domaines_ES
dc.subjectAmyloid beta peptidees_ES
dc.subjectAmyloid precursor proteines_ES
dc.subjectNeural progenitor cellses_ES
dc.subjectNeural stem cellses_ES
dc.subjectNeurogenesises_ES
dc.subjectSignaling pathwayses_ES
dc.subjectSoluble APP alphaes_ES
dc.subjectSoluble APP betaes_ES
dc.titlePhysiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involvedes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID31169172es_ES
dc.format.volume14es_ES
dc.format.number10es_ES
dc.format.page1661-1671es_ES
dc.identifier.doi10.4103/1673-5374.257511es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderComunidad de Madrid (España) 
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.4103/1673-5374.257511es_ES
dc.identifier.journalNeural regeneration researches_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)::Unidad de Regeneración Neurales_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI-10/00291es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MPY1412/09es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-71140-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/S2010/BMD-2336es_ES
dc.rights.accessRightsopen accesses_ES


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