Mostrar el registro sencillo del ítem

dc.contributor.authorPineda-Tenor, Daniel 
dc.contributor.authorBerenguer, Juan
dc.contributor.authorJimenez-Sousa, Maria Angeles 
dc.contributor.authorCarrero, Ana
dc.contributor.authorGarcia-Alvarez, Monica 
dc.contributor.authorAldámiz-Echevarria, Teresa
dc.contributor.authorGarcia-Broncano, Pilar 
dc.contributor.authorDiez, Cristina
dc.contributor.authorGuzman-Fulgencio, Maria 
dc.contributor.authorFernandez-Rodriguez, Amanda 
dc.contributor.authorResino, Salvador 
dc.date.accessioned2019-11-18T13:07:28Z
dc.date.available2019-11-18T13:07:28Z
dc.date.issued2015-03
dc.identifier.citationAIDS Res Hum Retroviruses. 2015 Mar;31(3):326-34. doi: 10.1089/aid.2014.0195. Epub 2014 Oct 29.es_ES
dc.identifier.issn0889-2229es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8602
dc.description.abstractTranscription factor 7 like 2 (TCF7L2) rs7903146 polymorphism has been associated with metabolic disturbance and cardiovascular disease. The aim of this study was to analyze the association between TCF7L2 rs7903146 polymorphism and potential disturbances on the lipid profile in human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients. We performed a cross-sectional study on 263 HIV/HVC-coinfected patients. TCF7L2 polymorphism was genotyped by GoldenGate assay. The analysis was performed by linear and logistic regression under a dominant model of inheritance. The variables analyzed were total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), non-HDL-C, and triglycerides. Patients harboring the rs7903146 TT/TC genotype showed a diminished concentration of TC (p=0.003), LDL-C (p=0.004), HDL-C (p=0.012), and non-HDL-C (p=0.013), a lower percentage of TC≥200 mg/dl (p=0.038), and a higher percentage of HDL≤40 mg/dl (p=0.023). In addition, we observed that rs7903146 was differently related to fasting serum lipid levels according to the HCV-genotype (HCV-GT). With regard to HCV-GT1 patients, the rs7903146 TT/TC genotype was associated with lower levels of HDL-C [adjusted arithmetic mean ratio (aAMR)=0.91; p=0.049] and an elevated percentage of patients with HDL-C≤40 mg/dl [adjusted odds ratio (aOR)=3.26; p=0.003]. For HCV-GT3 patients, the rs7903146 TT/TC genotype was associated with lower serum values of TC (aAMR=0.81; p=0.037), LDL-C (aAMR=0.67; p=0.001), and non-HDL-C (aAMR=0.75; p=0.002) and a reduced percentage of TC≥200 mg/dl (aOR=0.089; p=0.037). In conclusion, the TCF7L2 rs7903146 TT/TC genotype was associated with lower levels of TC, LDL, and HDL in HCV-GT3 patients, and lower levels of HDL-C in HCV-GT1 patients, suggesting a role in cardiovascular disease and a potential use as a biomarker in HIV/HCV-coinfected patients.es_ES
dc.description.sponsorshipD.P.T., M.A.JS., and M.G.A. have received research funding from “Instituto de Salud Carlos III” [grants CM12/00043, CM10/00105, and CD12/00442, respectively]. J.B. is an investigator from the Programa de Intensificación de la Actividad Investigadora en el Sistema Nacional de Salud (I3SNS). This work has been supported by grants from Fondo de Investigación de Sanidad en España (FIS) [Spanish Health Funds for Research] [grants PI08/0738, PI11/00245; PI08/0928, and PI11/01556], and “Fundación para la Investigación y la Prevención del Sida en España” (FIPSE) [grant 361020/10]. This work has been (partially) funded by the RD12/0017/0024 and RD12/0017/0004 projects as part of the Plan Nacional R+D+I and cofinanced by ISCIII––Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER).es_ES
dc.language.isoenges_ES
dc.publisherMary Ann Liebert es_ES
dc.type.hasVersionAMes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAdult es_ES
dc.subject.meshCholesterol es_ES
dc.subject.meshCross-Sectional Studies es_ES
dc.subject.meshDyslipidemias es_ES
dc.subject.meshFemale es_ES
dc.subject.meshGenotype es_ES
dc.subject.meshHIV es_ES
dc.subject.meshHIV Infections es_ES
dc.subject.meshHepatitis C, Chronic es_ES
dc.subject.meshHumans es_ES
dc.subject.meshLipoproteins es_ES
dc.subject.meshMale es_ES
dc.subject.meshTranscription Factor 7-Like 2 Protein es_ES
dc.subject.meshTriglycerides es_ES
dc.subject.meshGenetic Predisposition to Disease es_ES
dc.subject.meshGenetic Variation es_ES
dc.titlers7903146 polymorphism at transcription factor 7 like 2 gene is associated with total cholesterol and lipoprotein profile in HIV/hepatitis C virus-coinfected patientses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID25353718es_ES
dc.format.volume31es_ES
dc.format.number3es_ES
dc.format.page326-34es_ES
dc.identifier.doi10.1089/aid.2014.0195es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderFundación para la Investigación y la Prevención del Sida en España 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1931-8405es_ES
dc.relation.publisherversionhttps://doi.org/10.1089/aid.2014.0195es_ES
dc.identifier.journalAIDS research and human retroviruseses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/CM12/00043es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/CM10/00105es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/CD12/00442es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/PI08/0738es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/PI11/00245es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/PI08/0928es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/PI11/01556es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/361020/10es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/RD12/0017/0024es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/RD12/0017/0004es_ES
dc.rights.accessRightsopen accesses_ES


Ficheros en el ítem

Acceso Abierto
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución-NoComercial-CompartirIgual 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución-NoComercial-CompartirIgual 4.0 Internacional