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dc.contributor.author | Pineda-Tenor, Daniel | |
dc.contributor.author | Berenguer, Juan | |
dc.contributor.author | Jimenez-Sousa, Maria Angeles | |
dc.contributor.author | Carrero, Ana | |
dc.contributor.author | Garcia-Alvarez, Monica | |
dc.contributor.author | Aldámiz-Echevarria, Teresa | |
dc.contributor.author | Garcia-Broncano, Pilar | |
dc.contributor.author | Diez, Cristina | |
dc.contributor.author | Guzman-Fulgencio, Maria | |
dc.contributor.author | Fernandez-Rodriguez, Amanda | |
dc.contributor.author | Resino, Salvador | |
dc.date.accessioned | 2019-11-18T13:07:28Z | |
dc.date.available | 2019-11-18T13:07:28Z | |
dc.date.issued | 2015-03 | |
dc.identifier.citation | AIDS Res Hum Retroviruses. 2015 Mar;31(3):326-34. doi: 10.1089/aid.2014.0195. Epub 2014 Oct 29. | es_ES |
dc.identifier.issn | 0889-2229 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8602 | |
dc.description.abstract | Transcription factor 7 like 2 (TCF7L2) rs7903146 polymorphism has been associated with metabolic disturbance and cardiovascular disease. The aim of this study was to analyze the association between TCF7L2 rs7903146 polymorphism and potential disturbances on the lipid profile in human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients. We performed a cross-sectional study on 263 HIV/HVC-coinfected patients. TCF7L2 polymorphism was genotyped by GoldenGate assay. The analysis was performed by linear and logistic regression under a dominant model of inheritance. The variables analyzed were total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), non-HDL-C, and triglycerides. Patients harboring the rs7903146 TT/TC genotype showed a diminished concentration of TC (p=0.003), LDL-C (p=0.004), HDL-C (p=0.012), and non-HDL-C (p=0.013), a lower percentage of TC≥200 mg/dl (p=0.038), and a higher percentage of HDL≤40 mg/dl (p=0.023). In addition, we observed that rs7903146 was differently related to fasting serum lipid levels according to the HCV-genotype (HCV-GT). With regard to HCV-GT1 patients, the rs7903146 TT/TC genotype was associated with lower levels of HDL-C [adjusted arithmetic mean ratio (aAMR)=0.91; p=0.049] and an elevated percentage of patients with HDL-C≤40 mg/dl [adjusted odds ratio (aOR)=3.26; p=0.003]. For HCV-GT3 patients, the rs7903146 TT/TC genotype was associated with lower serum values of TC (aAMR=0.81; p=0.037), LDL-C (aAMR=0.67; p=0.001), and non-HDL-C (aAMR=0.75; p=0.002) and a reduced percentage of TC≥200 mg/dl (aOR=0.089; p=0.037). In conclusion, the TCF7L2 rs7903146 TT/TC genotype was associated with lower levels of TC, LDL, and HDL in HCV-GT3 patients, and lower levels of HDL-C in HCV-GT1 patients, suggesting a role in cardiovascular disease and a potential use as a biomarker in HIV/HCV-coinfected patients. | es_ES |
dc.description.sponsorship | D.P.T., M.A.JS., and M.G.A. have received research funding from “Instituto de Salud Carlos III” [grants CM12/00043, CM10/00105, and CD12/00442, respectively]. J.B. is an investigator from the Programa de Intensificación de la Actividad Investigadora en el Sistema Nacional de Salud (I3SNS). This work has been supported by grants from Fondo de Investigación de Sanidad en España (FIS) [Spanish Health Funds for Research] [grants PI08/0738, PI11/00245; PI08/0928, and PI11/01556], and “Fundación para la Investigación y la Prevención del Sida en España” (FIPSE) [grant 361020/10]. This work has been (partially) funded by the RD12/0017/0024 and RD12/0017/0004 projects as part of the Plan Nacional R+D+I and cofinanced by ISCIII––Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Mary Ann Liebert | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Cholesterol | es_ES |
dc.subject.mesh | Cross-Sectional Studies | es_ES |
dc.subject.mesh | Dyslipidemias | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Genotype | es_ES |
dc.subject.mesh | HIV | es_ES |
dc.subject.mesh | HIV Infections | es_ES |
dc.subject.mesh | Hepatitis C, Chronic | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Lipoproteins | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Transcription Factor 7-Like 2 Protein | es_ES |
dc.subject.mesh | Triglycerides | es_ES |
dc.subject.mesh | Genetic Predisposition to Disease | es_ES |
dc.subject.mesh | Genetic Variation | es_ES |
dc.title | rs7903146 polymorphism at transcription factor 7 like 2 gene is associated with total cholesterol and lipoprotein profile in HIV/hepatitis C virus-coinfected patients | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 25353718 | es_ES |
dc.format.volume | 31 | es_ES |
dc.format.number | 3 | es_ES |
dc.format.page | 326-34 | es_ES |
dc.identifier.doi | 10.1089/aid.2014.0195 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Fundación para la Investigación y la Prevención del Sida en España | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1931-8405 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1089/aid.2014.0195 | es_ES |
dc.identifier.journal | AIDS research and human retroviruses | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CM12/00043 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CM10/00105 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CD12/00442 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/PI08/0738 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/PI11/00245 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/PI08/0928 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/PI11/01556 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/361020/10 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/RD12/0017/0024 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/RD12/0017/0004 | es_ES |
dc.rights.accessRights | open access | es_ES |