Mostrar el registro sencillo del ítem

dc.contributor.authorOteo-Iglesias, Jesus 
dc.contributor.authorOrtega, Adriana 
dc.contributor.authorBartolomé, Rosa
dc.contributor.authorBou, Germán
dc.contributor.authorConejo, Carmen
dc.contributor.authorFernández-Martínez, Marta
dc.contributor.authorGonzález-López, Juan José
dc.contributor.authorMartínez-García, Laura
dc.contributor.authorMartínez-Martínez, Luis
dc.contributor.authorMerino, María
dc.contributor.authorMiró, Elisenda
dc.contributor.authorMora, Marta
dc.contributor.authorNavarro, Ferran
dc.contributor.authorOliver, Antonio
dc.contributor.authorPascual, Álvaro
dc.contributor.authorRodríguez-Baño, Jesús
dc.contributor.authorRuiz-Carrascoso, Guillermo
dc.contributor.authorRuiz-Garbajosa, Patricia
dc.contributor.authorZamorano, Laura
dc.contributor.authorBautista, Veronica 
dc.contributor.authorPerez-Vazquez, Maria 
dc.contributor.authorCampos, Jose 
dc.date.accessioned2019-11-14T10:53:22Z
dc.date.available2019-11-14T10:53:22Z
dc.date.issued2015
dc.identifier.citationAntimicrob Agents Chemother. 2015;59(6):3406-12.es_ES
dc.identifier.issn0066-4804es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8590
dc.description.abstractThe aim of this study was to determine the impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2013 by describing the prevalence, dissemination, and geographic distribution of CPE clones, and their population structure and antibiotic susceptibility. From February 2013 to May 2013, 83 hospitals (about 40,000 hospital beds) prospectively collected nonduplicate Enterobacteriaceae using the screening cutoff recommended by EUCAST. Carbapenemase characterization was performed by phenotypic methods and confirmed by PCR and sequencing. Multilocus sequencing types (MLST) were determined for Klebsiella pneumoniae and Escherichia coli. A total of 702 Enterobacteriaceae isolates met the inclusion criteria; 379 (54%) were CPE. OXA-48 (71.5%) and VIM-1 (25.3%) were the most frequent carbapenemases, and K. pneumoniae (74.4%), Enterobacter cloacae (10.3%), and E. coli (8.4%) were the species most affected. Susceptibility to colistin, amikacin, and meropenem was 95.5%, 81.3%, and 74.7%, respectively. The most prevalent sequence types (STs) were ST11 and ST405 for K. pneumoniae and ST131 for E. coli. Forty-five (54.1%) of the hospitals had at least one CPE case. For K. pneumoniae, ST11/OXA-48, ST15/OXA-48, ST405/OXA-48, and ST11/VIM-1 were detected in two or more Spanish provinces. ST11 isolates carried four carbapenemases (VIM-1, OXA-48, KPC-2, and OXA-245), but ST405 isolates carried OXA-48 only. A wide interregional spread of CPE in Spain was observed, mainly due to a few successful clones of OXA-48-producing K. pneumoniae (e.g., ST11 and ST405). The dissemination of OXA-48-producing E. coli is a new finding of public health concern. According to the susceptibilities determined in vitro, most of the CPE (94.5%) had three or more options for antibiotic treatment.es_ES
dc.description.sponsorshipThis work was supported by a grant from the Fondo de Investigación Sanitaria (grant PI12/01242); the Antibiotic Resistance Surveillance Programme of the Spanish Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad; the Plan Nacional de I+D+I 2008–2011; and the Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD12/0015), cofinanced by the European Development Regional Fund (ERDF) “A way to achieve Europe.”es_ES
dc.language.isoenges_ES
dc.publisherAmerican Society for Microbiology (ASM) es_ES
dc.type.hasVersionAMes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAged es_ES
dc.subject.meshAnti-Bacterial Agents es_ES
dc.subject.meshBacterial Proteins es_ES
dc.subject.meshColistin es_ES
dc.subject.meshEnterobacteriaceae es_ES
dc.subject.meshEscherichia coli es_ES
dc.subject.meshHumans es_ES
dc.subject.meshKlebsiella pneumoniae es_ES
dc.subject.meshMeropenem es_ES
dc.subject.meshMicrobial Sensitivity Tests es_ES
dc.subject.meshMultilocus Sequence Typing es_ES
dc.subject.meshProspective Studies es_ES
dc.subject.meshSpain es_ES
dc.subject.meshThienamycins es_ES
dc.subject.meshbeta-Lactamases es_ES
dc.titleProspective multicenter study of carbapenemase-producing Enterobacteriaceae from 83 hospitals in Spain reveals high in vitro susceptibility to colistin and meropenemes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID25824224es_ES
dc.format.volume59es_ES
dc.format.number6es_ES
dc.format.page3406-12es_ES
dc.identifier.doi10.1128/AAC.00086-15es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderRETICS-Investigación en Patología Infecciosa (REIPI-ISCIII) (España) 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1098-6596es_ES
dc.relation.publisherversionhttps://doi.org/10.1128/AAC.00086-15es_ES
dc.identifier.journalAntimicrobial agents and chemotherapyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/PI12/01242es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/REIPI RD12/0015es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/es_ES
dc.rights.accessRightsopen accesses_ES


Ficheros en el ítem

Acceso Abierto
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución-NoComercial-CompartirIgual 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución-NoComercial-CompartirIgual 4.0 Internacional