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dc.contributor.authorRodriguez-Garcia, Mercedes 
dc.contributor.authorBoros, Peter
dc.contributor.authorBromberg, Jonathan S
dc.contributor.authorCano-Ochando, Jordi 
dc.date.accessioned2019-11-08T12:18:55Z
dc.date.available2019-11-08T12:18:55Z
dc.date.issued2010-08
dc.identifier.citationCurr Opin Organ Transplant. 2010 Aug;15(4):416-21. doi: 10.1097/MOT.0b013e32833bcf5e.es_ES
dc.identifier.issn1087-2418es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8569
dc.description.abstractPURPOSE OF REVIEW: Understanding the interplay between myeloid dendritic cells and T cells under tolerogenic conditions, and whether their interactions induce the development of antigen-specific regulatory T cells (Tregs) is critical to uncover the mechanisms involved in the induction of indefinite allograft survival. RECENT FINDINGS: Myeloid dendritic cell-T-cell interactions are seminal events that determine the outcome of the immune response, and multiple in-vitro protocols suggest the generation of tolerogenic myeloid dendritic cells that modulate T-cell responses, and determine the outcome of the immune response to an allograft following adoptive transfer. We believe that identifying specific conditions that lead to the generation of tolerogenic myeloid dendritic cells and Tregs are critical for the manipulation of the immune response towards the development of transplantation tolerance. SUMMARY: We summarize recent findings regarding specific culture conditions that generate tolerogenic myeloid dendritic cells that induce T-cell hyporesponsiveness and Treg development, which represents a novel immunotherapeutic approach to promote the induction of indefinite graft survival prolongation. The interpretations presented here illustrate that different mechanisms govern the generation of tolerogenic myeloid dendritic cells, and we discuss the concomitant therapeutic implications.es_ES
dc.description.sponsorshipThis work was supported by the Programa Ramón y Cajal RYC-2006-1588, Ministerio de Educa-ción y Ciencia SAF2007-63579, Programa José Castillejo JC2008-00065, and Programa de Investigación de Grupos Emergentes del ISCIII (to J.C.O.), and NIH R01 AI-41428, AI-72039, and the Emerald Foundation (to J.S.B.).es_ES
dc.language.isoenges_ES
dc.publisherLippincott, Williams & Wilkinses_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimals es_ES
dc.subject.meshCell Culture Techniques es_ES
dc.subject.meshCells, Cultured es_ES
dc.subject.meshDendritic Cells es_ES
dc.subject.meshGraft Rejection es_ES
dc.subject.meshHumans es_ES
dc.subject.meshImmunotherapy es_ES
dc.subject.meshMyeloid Cells es_ES
dc.subject.meshT-Lymphocytes, Regulatory es_ES
dc.subject.meshGraft Survival es_ES
dc.subject.meshTransplantation Tolerance es_ES
dc.titleImmunotherapy with myeloid cells for tolerance inductiones_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID20616727es_ES
dc.format.volume15es_ES
dc.format.number4es_ES
dc.format.page416-21es_ES
dc.identifier.doi10.1097/MOT.0b013e32833bcf5ees_ES
dc.contributor.funderMinisterio de Educación y Ciencia (España)
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.description.peerreviewedes_ES
dc.identifier.e-issn1531-7013es_ES
dc.relation.publisherversionhttps://doi.org/10.1097/MOT.0b013e32833bcf5ees_ES
dc.identifier.journalCurrent opinion in organ transplantationes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RYC-2006-1588es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2007-63579es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/JC2008-00065es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/NIH R01 AI-41428es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/AI-72039es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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