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dc.contributor.authorOteo-Iglesias, Jesus 
dc.contributor.authorNavarro Rivas, Carmen 
dc.contributor.authorCercenado, Emilia
dc.contributor.authorDelgado-Iribarren, Alberto
dc.contributor.authorWilhelmi, Isabel
dc.contributor.authorOrden, Beatriz
dc.contributor.authorGarcia, Carmen 
dc.contributor.authorMiguelañez, Silvia 
dc.contributor.authorPerez-Vazquez, Maria 
dc.contributor.authorGarcía-Cobos, Silvia 
dc.contributor.authorAracil, Belen 
dc.contributor.authorBautista, Veronica 
dc.contributor.authorCampos, Jose 
dc.date.accessioned2019-10-22T10:01:01Z
dc.date.available2019-10-22T10:01:01Z
dc.date.issued2006-07
dc.identifier.citationJ Clin Microbiol. 2006 Jul;44(7):2359-66.es_ES
dc.identifier.issn0095-1137es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8517
dc.description.abstractA total of 151 Escherichia coli strains resistant to cefotaxime and ceftazidime were isolated during a prospective surveillance study. These strains were characterized by clinical, microbiological, and molecular analyses and were distributed into four clusters of 103, 11, 6, and 5 isolates, along with 25 unrelated strains. The principal cluster was isolated from urine, wound, blood, and other samples in three hospitals, eight nursing homes, and a community healthcare center. This cluster was associated with both nosocomial (65%) and community-acquired (35%) infections. Most strains were resistant to ciprofloxacin, gentamicin, tobramycin, cefepime, amoxicillin-clavulanic acid, and trimethoprim-sulfamethoxazole but were susceptible to imipenem. All isolates from the four clusters expressed the extended-spectrum beta-lactamase (ESBL) CTX-M-15. This enzyme was also present in 8 (30.8%) of the 26 unrelated isolates. The other ESBLs, CTX-M-14 and CTX-M-32, were detected in five and seven cases, respectively, but they were detected in individual E. coli isolates only. In three clusters, blaCTX-M-15 alleles were linked to an ISEcp1-like element, while in eight strains of cluster II an IS26 element preceded the blaCTX-M-15 allele. An additional pool of resistance genes included tetA, drfA14 or dfrA17, sul1 or sul2, aac(6')Ib, and aac(3)IIb. All except one of the 27 isolates tested for genetic virulence markers harbored the same three virulence genes: iutA and fyuA (siderophores), and traT (serum survival factor). Epidemic or occasional isolates of cefotaxime- and ceftazidime-resistant E. coli can spread between distinct health facilities including hospitals, community health centers, and long-term care centers.es_ES
dc.description.sponsorshipThis study was supported by research grants from the Instituto de Salud Carlos III, Programa Intramural (reference 03/ESP32); the Fondo de Investigaciones Sanitarias, Ministry of Health, Madrid, Spain (FIS PI040837); and the Red Española de Investigación en Patología Infecciosa (REIPI). J.O. was supported by the Dirección General de Salud Pública, Ministry of Health, Madrid, Spain (reference SBVI1284/02-13).es_ES
dc.language.isoenges_ES
dc.publisherAmerican Society for Microbiology (ASM) es_ES
dc.type.hasVersionAMes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAdolescent es_ES
dc.subject.meshAdult es_ES
dc.subject.meshAnti-Bacterial Agents es_ES
dc.subject.meshBacterial Outer Membrane Proteins es_ES
dc.subject.meshBlood es_ES
dc.subject.meshCefotaxime es_ES
dc.subject.meshCeftazidime es_ES
dc.subject.meshCluster Analysis es_ES
dc.subject.meshCommunity-Acquired Infections es_ES
dc.subject.meshCross Infection es_ES
dc.subject.meshDNA Transposable Elements es_ES
dc.subject.meshEscherichia coli es_ES
dc.subject.meshEscherichia coli Infections es_ES
dc.subject.meshEscherichia coli Proteins es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshMicrobial Sensitivity Tests es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshMolecular Epidemiology es_ES
dc.subject.meshReceptors, Cell Surface es_ES
dc.subject.meshSpain es_ES
dc.subject.meshUrine es_ES
dc.subject.meshVirulence es_ES
dc.subject.meshWounds and Injuries es_ES
dc.subject.meshbeta-Lactamases es_ES
dc.subject.meshbeta-Lactam Resistance es_ES
dc.titleSpread of Escherichia coli strains with high-level cefotaxime and ceftazidime resistance between the community, long-term care facilities, and hospital institutionses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID16825350es_ES
dc.format.volume44es_ES
dc.format.number7es_ES
dc.format.page2359-66es_ES
dc.identifier.doi10.1128/JCM.00447-06es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderRETICS-Investigación en Patología Infecciosa (REIPI-ISCIII) (España) 
dc.relation.publisherversionhttps://doi.org/10.1128/JCM.00447-06es_ES
dc.identifier.journalJournal of clinical microbiologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/03/ESP32es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FIS PI040837es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SBVI1284/02-13es_ES
dc.rights.accessRightsopen accesses_ES


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