Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/8500
Título
Sestrins as a Therapeutic Bridge between ROS and Autophagy in Cancer
Autor(es)
Fecha de publicación
2019-09
Cita
Cancers (Basel). 2019, 11(10): E1415
Idioma
Inglés
Tipo de documento
journal article
Resumen
: The regulation of Reactive Oxygen Species (ROS) levels and the contribution therein from networks regulating cell metabolism, such as autophagy and the mTOR-dependent nutrient-sensing pathway, constitute major targets for selective therapeutic intervention against several types of tumors, due to their extensive rewiring in cancer cells as compared to healthy cells. Here, we discuss the sestrin family of proteins-homeostatic transducers of oxidative stress, and drivers of antioxidant and metabolic adaptation-as emerging targets for pharmacological intervention. These adaptive regulators lie at the intersection of those two priority nodes of interest in antitumor intervention-ROS control and the regulation of cell metabolism and autophagy-therefore, they hold the potential not only for the development of completely novel compounds, but also for leveraging on synergistic strategies with current options for tumor therapy and classification/stadiation to achieve personalized medicine.
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Versión en línea
DOI
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