Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/8496
Título
Epigenetic Strategies to Boost Cancer Immunotherapies
Autor(es)
Barrero, Maria Jose CNIO
Fecha de publicación
2017-05-23
Cita
Int J Mol Sci. 2017;18(6). pii: E1108.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Recently, immunotherapeutic approaches have shown impressive responses in a subset of cancer patients. However, the rate of success is low and a large percentage of treated patients do not experience clinical benefits. Therefore, additional strategies are needed to improve responses and select responsive patients. Emerging data suggest that epigenetic drugs can improve the responses to immunotherapy. Understanding the mechanisms of resistance to immunotherapy and the epigenetic events that take place during immune evasion is critical to providing a rational combined use of immunotherapies and epigenetic drugs. This review focuses in the epigenetic mechanisms involved in the responses to immunotherapy and how current drugs that target epigenetic regulators impact on them.
Palabras clave
MESH
Descripción
The CNIO- Lilly Epigenetics Laboratory is supported by Eli Lilly and Company.
Versión en línea
DOI
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