Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/8364
Título
Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location
Autor(es)
Brandariz, Lorena | Arriba, María | García, Juan Luis | Cano, Juana María | Rueda, Daniel | Rubio, Eduardo | Rodríguez, Yolanda | Pérez, Jessica | Vivas, Alfredo | Sánchez, Carmen | Tapial, Sandra | Pena, Laura | García-Arranz, Mariano | García-Olmo, Damián | Urioste, Miguel CNIO | González-Sarmiento, Rogelio | Perea, José
Fecha de publicación
2018-03-16
Cita
Oncotarget. 2018 ;9(20):15302-15311.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Background: Since there is a predilection of some clinical and molecular features for a given tumor location, we assessed whether this can be confirmed in late-onset colorectal cancer (LOCRC). Results: Right colon cancers showed features associated with sporadic Microsatellite Instability: predominance of female cases and BRAF mutations, and an important mucinous component. Left colon cancers developed a higher number of polyps and multiple primary CRCs, showed the strongest familial component, and had better prognosis. Rectal cancers showed a predominantly sporadic phenotype, with worse prognosis and a CpG Island Methylator Phenotype (CIMP)-High. No copy number alterations (CNAs) greater than or equal to 50% were observed in this LOCRC group, and the most recurrent alterations were losses at 5q13 and 14q11, and gains at 7q11, 7q21-q22, 19p13-p12, 19q13 and 20p11-q11. KRAS and PIK3CA were the only mutated genes showing differences according to the tumor location, mainly for right colon cancers. Materials and Methods: We analyzed clinical and molecular characteristics of LOCRC at different tumor locations in order to determine if there are differential phenotypes related with the location in the colon. Conclusions: Categorizing LOCRC according to tumor location appears to be an adequate first step to resolving the heterogeneity of this subset of CRC.
Palabras clave
CpG island methylator phenotype | chromosomal instability | colon location | late-onset colorectal cancer | microsatellite instability
Versión en línea
DOI
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