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dc.contributor.authorBrandariz, Lorena
dc.contributor.authorArriba, María
dc.contributor.authorGarcía, Juan Luis
dc.contributor.authorCano, Juana María
dc.contributor.authorRueda, Daniel
dc.contributor.authorRubio, Eduardo
dc.contributor.authorRodríguez, Yolanda
dc.contributor.authorPérez, Jessica
dc.contributor.authorVivas, Alfredo
dc.contributor.authorPons-Sanchez, Carmen 
dc.contributor.authorTapial, Sandra
dc.contributor.authorPena, Laura
dc.contributor.authorGarcía-Arranz, Mariano
dc.contributor.authorGarcía-Olmo, Damián
dc.contributor.authorUrioste, Miguel 
dc.contributor.authorGonzález-Sarmiento, Rogelio
dc.contributor.authorPerea, José
dc.date.accessioned2019-09-23T09:38:49Z
dc.date.available2019-09-23T09:38:49Z
dc.date.issued2018-03-16
dc.identifier.citationOncotarget. 2018 ;9(20):15302-15311.es_ES
dc.identifier.issn1949-2553es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8364
dc.description.abstractBackground: Since there is a predilection of some clinical and molecular features for a given tumor location, we assessed whether this can be confirmed in late-onset colorectal cancer (LOCRC). Results: Right colon cancers showed features associated with sporadic Microsatellite Instability: predominance of female cases and BRAF mutations, and an important mucinous component. Left colon cancers developed a higher number of polyps and multiple primary CRCs, showed the strongest familial component, and had better prognosis. Rectal cancers showed a predominantly sporadic phenotype, with worse prognosis and a CpG Island Methylator Phenotype (CIMP)-High. No copy number alterations (CNAs) greater than or equal to 50% were observed in this LOCRC group, and the most recurrent alterations were losses at 5q13 and 14q11, and gains at 7q11, 7q21-q22, 19p13-p12, 19q13 and 20p11-q11. KRAS and PIK3CA were the only mutated genes showing differences according to the tumor location, mainly for right colon cancers. Materials and Methods: We analyzed clinical and molecular characteristics of LOCRC at different tumor locations in order to determine if there are differential phenotypes related with the location in the colon. Conclusions: Categorizing LOCRC according to tumor location appears to be an adequate first step to resolving the heterogeneity of this subset of CRC.es_ES
dc.description.sponsorshipThis work was funded by Projects PI10/0683,PI13/01741, PI13/0127 and PI14/00459 from the Spanish Ministry of Health and Consumer Affairs and FEDER,and was approved by the Ethics Committee of our Institution.es_ES
dc.language.isoenges_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectCpG island methylator phenotypees_ES
dc.subjectchromosomal instabilityes_ES
dc.subjectcolon locationes_ES
dc.subjectlate-onset colorectal canceres_ES
dc.subjectmicrosatellite instabilityes_ES
dc.titleDifferential clinicopathological and molecular features within late-onset colorectal cancer according to tumor locationes_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID29632645es_ES
dc.format.volume9es_ES
dc.format.number20es_ES
dc.format.page15302-15311es_ES
dc.identifier.doi10.18632/oncotarget.24502es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1949-2553es_ES
dc.relation.publisherversionhttps://doi.org/10.18632/oncotarget.24502.es_ES
dc.identifier.journalOncotargetes_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Unidades técnicas::Unidad Clínica de Cáncer Familiares_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI10/0683es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI13/01741es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI13/0127es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/00459es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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