Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/8335
Título
Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells
Autor(es)
Andres-Delgado, Laura CNIC | Ernst, Alexander | Galardi-Castilla, Maria CNIC | Bazaga, David CNIC | Peralta, Marina CNIC | Munch, Juliane CNIC | Gonzalez-Rosa, Juan Manuel CNIC | Marques, Inês | Tessadori, Federico | de la Pompa, Jose Luis CNIC | Vermot, Julien | Mercader, Nadia CNIC
Fecha de publicación
2019-07
Cita
Development. 2019; 146(13):dev174961
Idioma
Inglés
Tipo de documento
journal article
Resumen
The epicardium, the outer mesothelial layer enclosing the myocardium, plays key roles in heart development and regeneration. During embryogenesis, the epicardium arises from the proepicardium (PE), a cell cluster that appears in the dorsal pericardium (DP) close to the venous pole of the heart. Little is known about how the PE emerges from the pericardial mesothelium. Using a zebrafish model and a combination of genetic tools, pharmacological agents and quantitative in vivo imaging, we reveal that a coordinated collective movement of DP cells drives PE formation. We found that Bmp signaling and the actomyosin cytoskeleton promote constriction of the DP, which enables PE cells to extrude apically. We provide evidence that cell extrusion, which has been described in the elimination of unfit cells from epithelia and the emergence of hematopoietic stem cells, is also a mechanism for PE cells to exit an organized mesothelium and fulfil their developmental fate to form a new tissue layer, the epicardium.
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