Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/8235
Título
Genetic characterization of fluoroquinolone-resistant Streptococcus pneumoniae strains isolated during ciprofloxacin therapy from a patient with bronchiectasis
Autor(es)
de la Campa, Adela G ISCIII | Ferrandiz-Avellano, Maria-Jose ISCIII | Tubau, Fe | Pallarés, Román | Manresa, Federico | Liñares, Josefina
Fecha de publicación
2003-04
Cita
Antimicrob Agents Chemother. 2003 Apr;47(4):1419-22.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Five Spain(9V-3) Streptococcus pneumoniae strains were isolated from a patient with bronchiectasis who had received long-term ciprofloxacin therapy. One ciprofloxacin-susceptible strain was isolated before treatment, and four ciprofloxacin-resistant strains were isolated during treatment. The resistant strains were derived from the susceptible strain either by a parC mutation (low-level resistance) or by parC and gyrA mutations (high-level resistance). This study shows that ciprofloxacin therapy in a patient colonized by susceptible S. pneumoniae may select fluoroquinolone-resistant mutants.
MESH
Anti-Infective Agents | Bronchiectasis | Ciprofloxacin | Drug Resistance, Bacterial | Humans | Male | Middle Aged | Streptococcus pneumoniae | Mutation
Versión en línea
DOI
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