Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/8235
Genetic characterization of fluoroquinolone-resistant Streptococcus pneumoniae strains isolated during ciprofloxacin therapy from a patient with bronchiectasis
de la Campa, Adela G ISCIII | Ferrandiz-Avellano, Maria-Jose ISCIII | Tubau, Fe | Pallarés, Román | Manresa, Federico | Liñares, Josefina
Antimicrob Agents Chemother. 2003 Apr;47(4):1419-22.
Five Spain(9V-3) Streptococcus pneumoniae strains were isolated from a patient with bronchiectasis who had received long-term ciprofloxacin therapy. One ciprofloxacin-susceptible strain was isolated before treatment, and four ciprofloxacin-resistant strains were isolated during treatment. The resistant strains were derived from the susceptible strain either by a parC mutation (low-level resistance) or by parC and gyrA mutations (high-level resistance). This study shows that ciprofloxacin therapy in a patient colonized by susceptible S. pneumoniae may select fluoroquinolone-resistant mutants.
Anti-Infective Agents | Bronchiectasis | Ciprofloxacin | Drug Resistance, Bacterial | Humans | Male | Middle Aged | Streptococcus pneumoniae | Mutation