Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7986
Título
Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models
Autor(es)
Villalba-Orero, Maria CNIC | Lopez-Olaneta, Marina CNIC | García-Pavía, Pablo | Lara-Pezzi, Enrique CNIC
Fecha de publicación
2017-12
Cita
J Cardiovasc Transl Res. 2017; 10(5-6):499-501
Idioma
Inglés
Tipo de documento
journal article
Resumen
Heart failure (HF) is a major cause of death and hospitalization worldwide. Despite advances in reducing mortality, prognosis remains poor and prevalence has reached epidemic proportions. The limitations of available preclinical models represent a major hurdle in the development of new therapies. Myocardial infarction (MI) is a main cause of HF in humans, and mouse models of MI are often used to study HF mechanisms and experimental treatments. We investigated whether MI in mice constitutes an appropriate model of HF. Permanent ligation of the left coronary artery induced severe and persistent systolic dysfunction and ventricular dilatation. Mouse follow-up for 10 months showed no significant evidence of lung congestion or other pulmonary defects associated with HF. No difference was observed in the capacity of infarcted mice to exercise compared to control animals. These results indicate that severe cardiac dysfunction in mice is not sufficient to demonstrate the presence of HF.
Palabras clave
MESH
Animals | Disease Models, Animal | Disease Progression | Heart Failure | Hypertrophy, Left Ventricular | Male | Mice, Inbred C57BL | Myocardial Infarction | Myocardium | Species Specificity | Stroke Volume | Systole | Time Factors | Ventricular Dysfunction, Left | Ventricular Remodeling | Ventricular Function, Left
Versión en línea
DOI
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