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dc.contributor.authorVillalba-Orero, Maria 
dc.contributor.authorLopez-Olaneta, Marina 
dc.contributor.authorGarcía-Pavía, Pablo
dc.contributor.authorLara-Pezzi, Enrique 
dc.date.accessioned2019-07-30T07:48:00Z
dc.date.available2019-07-30T07:48:00Z
dc.date.issued2017-12
dc.identifier.citationJ Cardiovasc Transl Res. 2017; 10(5-6):499-501es_ES
dc.identifier.issn1937-5387es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7986
dc.description.abstractHeart failure (HF) is a major cause of death and hospitalization worldwide. Despite advances in reducing mortality, prognosis remains poor and prevalence has reached epidemic proportions. The limitations of available preclinical models represent a major hurdle in the development of new therapies. Myocardial infarction (MI) is a main cause of HF in humans, and mouse models of MI are often used to study HF mechanisms and experimental treatments. We investigated whether MI in mice constitutes an appropriate model of HF. Permanent ligation of the left coronary artery induced severe and persistent systolic dysfunction and ventricular dilatation. Mouse follow-up for 10 months showed no significant evidence of lung congestion or other pulmonary defects associated with HF. No difference was observed in the capacity of infarcted mice to exercise compared to control animals. These results indicate that severe cardiac dysfunction in mice is not sufficient to demonstrate the presence of HF.es_ES
dc.description.sponsorshipThis work was supported by grants from the Spanish Ministry of Economy and Competitiveness (SAF2015-65722-R to E.L-P), Autonomous Community of Madrid (2010-BMD2321, FIBROTEAM Consortium), European Union's FP7 (CardioNeT-ITN-289600, CardioNext-ITN-608027 to E.L-P), the Spanish Carlos III Institute of Health (CPII14/00027 and RD12/0042/066 to E.L-P). This work was also supported by the Plan Estatal de I+D+I 2013-2016-European Regional Development Fund (FEDER) "A way of making Europe," Spain. The CNIC is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectHeart failurees_ES
dc.subjectMicees_ES
dc.subjectMyocardial infarctiones_ES
dc.subjectPreclinical modelses_ES
dc.subject.meshAnimals es_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshDisease Progression es_ES
dc.subject.meshHeart Failure es_ES
dc.subject.meshHypertrophy, Left Ventricular es_ES
dc.subject.meshMale es_ES
dc.subject.meshMice, Inbred C57BL es_ES
dc.subject.meshMyocardial Infarction es_ES
dc.subject.meshMyocardium es_ES
dc.subject.meshSpecies Specificity es_ES
dc.subject.meshStroke Volume es_ES
dc.subject.meshSystole es_ES
dc.subject.meshTime Factors es_ES
dc.subject.meshVentricular Dysfunction, Left es_ES
dc.subject.meshVentricular Remodeling es_ES
dc.subject.meshVentricular Function, Left es_ES
dc.titleSystolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Modelses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID28812262es_ES
dc.format.volume10es_ES
dc.format.number5-6es_ES
dc.format.page499-501es_ES
dc.identifier.doi10.1007/s12265-017-9765-xes_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderComunidad de Madrides_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1937-5395es_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s12265-017-9765-xes_ES
dc.identifier.journalJournal of cardiovascular translational researches_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Regulación Molecular de la Insuficiencia Cardiacaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/289600/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/608027/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-65722-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CPII14/00027es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0042/066es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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