Mostrar el registro sencillo del ítem
dc.contributor.author | Dorado, Beatriz | |
dc.contributor.author | Andres, Vicente | |
dc.date.accessioned | 2019-07-19T08:47:19Z | |
dc.date.available | 2019-07-19T08:47:19Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Curr Opin Cell Biol. 2017; 46:17-25 | es_ES |
dc.identifier.issn | 0955-0674 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7959 | |
dc.description.abstract | Lamin A is a nuclear intermediate filament protein with important structural and regulatory roles in most differentiated mammalian cells. Excessive accumulation of its precursor prelamin A or the mutant form called 'progerin' causes premature aging syndromes. Progeroid 'laminopathies' are characterized by severe cardiovascular problems (cardiac electrical defects, vascular calcification and stiffening, atherosclerosis, myocardial infarction, and stroke) and premature death. Here, we review studies in cell and mouse models and patients that are unraveling how abnormal prelamin A and progerin accumulation accelerates cardiovascular disease and aging. This knowledge is essential for developing effective therapies to treat progeria and may help identify new mechanisms underlying normal aging. | es_ES |
dc.description.sponsorship | Work in the laboratory of V.A. is supported by the Spanish Ministerio de Economia, Industria y Competitividad (MINECO) (SAF2013-46663-R) and the Instituto de Salud Carlos III (RD12/0042/0028) with co-funding from the Fondo Europeo de Desarrollo Regional (FEDER), the Fundacio Marato TV3 (122/C/2015), and the Progeria Research Foundation (Established Investigator Award 2014-52). The CNIC is supported by the MINECO and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject.mesh | Aging | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Cardiovascular Diseases | es_ES |
dc.subject.mesh | Cell Nucleus | es_ES |
dc.subject.mesh | Disease Models, Animal | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Lamin Type A | es_ES |
dc.subject.mesh | Progeria | es_ES |
dc.title | A-type lamins and cardiovascular disease in premature aging syndromes | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 28086161 | es_ES |
dc.format.volume | 46 | es_ES |
dc.format.page | 17-25 | es_ES |
dc.identifier.doi | 10.1016/j.ceb.2016.12.005 | es_ES |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Fundación La Marató TV3 | |
dc.contributor.funder | Progeria Research Foundation | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1879-0410 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.ceb.2016.12.005 | es_ES |
dc.identifier.journal | Current opinion in cell biology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Fisiopatología Cardiovascular Molecular y Genética | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2013-46663-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0042/0028 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.rights.accessRights | open access | es_ES |