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Título
A-type lamins and cardiovascular disease in premature aging syndromes
Autor(es)
Dorado, Beatriz CNIC | Andres, Vicente CNIC
Fecha de publicación
2017
Cita
Curr Opin Cell Biol. 2017; 46:17-25
Idioma
Inglés
Tipo de documento
journal article
Resumen
Lamin A is a nuclear intermediate filament protein with important structural and regulatory roles in most differentiated mammalian cells. Excessive accumulation of its precursor prelamin A or the mutant form called 'progerin' causes premature aging syndromes. Progeroid 'laminopathies' are characterized by severe cardiovascular problems (cardiac electrical defects, vascular calcification and stiffening, atherosclerosis, myocardial infarction, and stroke) and premature death. Here, we review studies in cell and mouse models and patients that are unraveling how abnormal prelamin A and progerin accumulation accelerates cardiovascular disease and aging. This knowledge is essential for developing effective therapies to treat progeria and may help identify new mechanisms underlying normal aging.
MESH
Aging | Animals | Cardiovascular Diseases | Cell Nucleus | Disease Models, Animal | Humans | Lamin Type A | Progeria
Versión en línea
DOI
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