Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7898
Título
DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis
Autor(es)
Fecha de publicación
2015
Cita
Molecular & Cellular Oncology, 2:1, e970048
Idioma
Inglés
Tipo de documento
journal article
Resumen
DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a kinase with multiple implications for embryonic development, especially in the nervous system where it regulates the balance between proliferation and differentiation of neural progenitors. The DYRK1A gene is located in the Down syndrome critical region and may play a significant role in the developmental brain defects, early neurodegeneration, and cancer susceptibility of individuals with this syndrome. DYRK1A is also expressed in adults, where it might participate in the regulation of cell cycle, survival, and tumorigenesis, thus representing a potential therapeutic target for certain types of cancer. However, the final readout of DYRK1A overexpression or inhibition depends strongly on the cellular context, as it has both tumor suppressor and oncogenic activities. Here, we will discuss the functions and substrates of DYRK1A associated with the control of cell growth and tumorigenesis with a focus on the potential use of DYRK1A inhibitors in cancer therapy.
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