Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7878
Título
Mechanisms of metabolic dysfunction in cancer-associated cachexia
Autor(es)
Fecha de publicación
2016-03-01
Cita
Genes Dev. 2016;30(5):489-501.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the adipose tissue. This systemic syndrome, termed cancer-associated cachexia (CAC), is a major cause of morbidity and mortality. While once attributed solely to decreased food intake, the present description of cancer cachexia is a disorder of multiorgan energy imbalance. Here we review the molecules and pathways responsible for metabolic dysfunction in CAC and the ideas that led to the current understanding.
Palabras clave
cancer-associated cachexia (CAC) | metabolic failure | skeletal muscle atrophy | white adipose tissue (WAT) browning
MESH
Adipose Tissue, White | Cachexia | Carbohydrate Metabolism | Endocrine System | Humans | Inflammation | Lipid Metabolism | Liver | Muscular Atrophy | Neoplasms
Versión en línea
DOI
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