2024-03-29T10:33:50Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/78782023-10-06T07:30:00Zcom_20.500.12105_2174com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_2175
00925njm 22002777a 4500
dc
Petruzzelli, Michele
author
Wagner, Erwin Friedrich
author
2016-03-01
Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the adipose tissue. This systemic syndrome, termed cancer-associated cachexia (CAC), is a major cause of morbidity and mortality. While once attributed solely to decreased food intake, the present description of cancer cachexia is a disorder of multiorgan energy imbalance. Here we review the molecules and pathways responsible for metabolic dysfunction in CAC and the ideas that led to the current understanding.
Genes Dev. 2016;30(5):489-501.
0890-9369
http://hdl.handle.net/20.500.12105/7878
26944676
10.1101/gad.276733.115
1549-5477
Genes & development
cancer-associated cachexia (CAC)
metabolic failure
skeletal muscle atrophy
white adipose tissue (WAT) browning
Mechanisms of metabolic dysfunction in cancer-associated cachexia