dc.contributor.author | Cossio, Itziar | |
dc.contributor.author | Lucas, Daniel | |
dc.contributor.author | Hidalgo, Andres | |
dc.date.accessioned | 2019-07-03T14:11:16Z | |
dc.date.available | 2019-07-03T14:11:16Z | |
dc.date.issued | 2019-05 | |
dc.identifier.citation | Blood. 2019; 133(20):2140-2148 | es_ES |
dc.identifier.issn | 0006-4971 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7849 | |
dc.description.abstract | The niche that supports hematopoietic stem and progenitor cells (HSPCs) in the bone marrow is a highly dynamic structure. It maintains core properties of HSPCs in the steady state, and modulates their proliferation and differentiation in response to changing physiological demands or pathological insults. The dynamic and environment-sensing properties of the niche are shared by the innate immune system. Thus, it is not surprising that innate immune cells, including macrophages and neutrophils, are now recognized as important regulators of the hematopoietic niche and, ultimately, of the stem cells from which they derive. This review synthesizes emerging concepts on niche regulation by immune cells, with a particular emphasis on neutrophils. We argue that the unique developmental, circadian, and migratory properties of neutrophils underlie their critical contributions as regulators of the hematopoietic niche. | es_ES |
dc.description.sponsorship | This work was supported in part by SAF2015-65607-R and Fondo Europeo de Desarrollo Regional (FEDER) (A.H.); Ministerio de Ciencia, Innovacion y Universidades (MCIU) for fellowship BES-2014-068915 (I.C.); and R01 HL136529-01 from the National Institutes of Health, National Heart, Lung, and Blood Institute (D.L.). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) was supported by the MCIU and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MCIU award SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society of Hematology (ASH) | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Neutrophils as regulators of the hematopoietic niche | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 30898859 | es_ES |
dc.format.volume | 133 | es_ES |
dc.format.number | 20 | es_ES |
dc.format.page | 2140-2148 | es_ES |
dc.identifier.doi | 10.1182/blood-2018-10-844571 | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | National Institutes of Health (Estados Unidos) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | es_ES |
dc.embargo.terms | 2020-05-01 | es_ES |
dc.identifier.e-issn | 1528-0020 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1182/blood-2018-10-844571 | es_ES |
dc.identifier.journal | Blood | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmune | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2015-65607-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/BES-2014-068915 | es_ES |
dc.rights.accessRights | open access | es_ES |