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dc.contributor.authorMartin-Galiano, Antonio Javier 
dc.contributor.authorFerrandiz-Avellano, Maria-Jose 
dc.contributor.authorde la Campa, Adela G 
dc.date.accessioned2019-06-04T11:38:07Z
dc.date.available2019-06-04T11:38:07Z
dc.date.issued2017
dc.identifier.citationGenome Biol Evol. 2017 Feb;9(2):350-361es_ES
dc.identifier.issn1759-6653es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7724
dc.description.abstractThe chromosome of Streptococcus pneumoniae is organized into topological domains based on its transcriptional response to DNA relaxation: Up-regulated (UP), down-regulated (DOWN), nonregulated (NR), and AT-rich. In the present work, NR genes found to have highly conserved chromosomal locations (17% of the genome) were categorized as members of position-conserved nonregulated (pcNR) domains, while NR genes with a variable position (36% of the genome) were classified as members of position-variable nonregulated (pvNR) domains. On average, pcNR domains showed high transcription rates, optimized codon usage, and were found to contain only a small number of RUP/BOX/SPLICE repeats. They were also poor in exogenous genes but enriched in leading strand genes that code for proteins involved in primary metabolism with central roles within the interactome. In contrast, pvNR genes coding for cell wall proteins, paralogs, virulence factors and immunogenic candidates for protein-based vaccines were found to be overrepresented. DOWN domains were enriched in genes essential for infection. Many UP and DOWN domain genes were seen to be activated during different stages of competence, whereas pcNR genes tended to be repressed until the competence was switched off. Pneumococcal genes appear to be subject to a topology-driven selection pressure that defines the chromosomal location of genes involved in metabolism, virulence and competence. The pcNR domains are interleaved between UP and DOWN domains according to a pattern that suggests the existence of macrodomain entities. The term "topogenomics" is here proposed to describe the study of the topological rules of genomes and their relationship with physiology.es_ES
dc.description.sponsorshipThis work was supportedby Ministry of Economy and Competitiveness [BIO2014-55462-R]es_ES
dc.language.isoenges_ES
dc.publisherOxford University Press es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectX-statees_ES
dc.subjectInteractomees_ES
dc.subjectTopoisomerasees_ES
dc.subjectTopological domaines_ES
dc.subjectVirulence factores_ES
dc.subject.meshChromosomes, Bacterial es_ES
dc.subject.meshConserved Sequence es_ES
dc.subject.meshSelection, Genetic es_ES
dc.subject.meshStreptococcus pneumoniae es_ES
dc.subject.meshTranscriptional Activation es_ES
dc.subject.meshTranscriptome es_ES
dc.subject.meshVirulence Factors es_ES
dc.subject.meshRegulatory Sequences, Nucleic Acid es_ES
dc.titleBridging Chromosomal Architecture and Pathophysiology of Streptococcus pneumoniaees_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID28158485es_ES
dc.format.volume9es_ES
dc.format.number2es_ES
dc.format.page350-361es_ES
dc.identifier.doi10.1093/gbe/evw299es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1759-6653es_ES
dc.relation.publisherversionhttps://doi.org/10.1093/gbe/evw299es_ES
dc.identifier.journalGenome biology and evolutiones_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BIO2014-55462-Res_ES
dc.rights.accessRightsopen accesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución-NoComercial-CompartirIgual 4.0 Internacional