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dc.contributor.authorLópez, Daniel 
dc.contributor.authorJimenez, Mercedes 
dc.contributor.authorGarcía-Calvo, Margarita
dc.contributor.authorDel Val, Margarita
dc.date.accessioned2019-06-03T11:30:48Z
dc.date.available2019-06-03T11:30:48Z
dc.date.issued2011-05-13
dc.identifier.citationJ Biol Chem. 2011;286(19):16910-3.es_ES
dc.identifier.issn0021-9258es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7709
dc.description.abstractThe generation of peptides presented by MHC class I molecules requires the proteolytic activity of the proteasome and/or other peptidases. The processing of a short vaccinia virus-encoded antigen can take place by a proteasome-independent pathway involving initiator caspase-5 and -10, which generate antigenic peptides recognized by CD8(+) T lymphocytes. In the present study, comparing single versus double enzyme digestions by mass spectrometry analysis, both qualitative and quantitative differences in the products obtained were identified. These in vitro data suggest that each enzyme can use the degradation products of the other as substrate for new cleavages, indicating concerted endoproteolytic activity of caspase-5 and -10.es_ES
dc.description.sponsorshipThis work was supported by grants provided by the European Union, Ministerio de Ciencia e Innovación, Comunidad de Madrid, and Instituto de Salud Carlos III (to M. D. V.) and by Programa Ramón y Cajal and FIPSE Foundation (to D. L.).es_ES
dc.language.isoenges_ES
dc.publisherAmerican Society for Biochemistry and Molecular Biologyes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleConcerted antigen processing of a short viral antigen by human caspase-5 and -10es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID21454616es_ES
dc.format.volume286es_ES
dc.format.number19es_ES
dc.format.page16910-3es_ES
dc.identifier.doi10.1074/jbc.M111.234658es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderComunidad de Madrides_ES
dc.contributor.funderFundación para la Innovación y la Prospectiva en Salud en España (FIPSE)es_ES
dc.contributor.funderEuropean Uniones_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1083-351Xes_ES
dc.relation.publisherversionhttps://www.doi.org/10.1074/jbc.M111.234658es_ES
dc.identifier.journalThe Journal of biological chemistryes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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