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dc.contributor.authorMartin-Odoom, Alexander
dc.contributor.authorBrown, Charles Addoquaye
dc.contributor.authorOdoom, John Kofi
dc.contributor.authorBonney, Evelyn Yayra
dc.contributor.authorNtim, Nana Afia Asante
dc.contributor.authorDelgado, Elena 
dc.contributor.authorLartey, Margaret
dc.contributor.authorSagoe, Kwamena William
dc.contributor.authorAdiku, Theophilus
dc.contributor.authorAmpofo, William Kwabena
dc.identifier.citationVirol J. 2018 Sep 17;15(1):143.es_ES
dc.description.abstractBACKGROUND: Antiretrovirals have been available in Ghana since 2003 for HIV-1 positive pregnant women for prevention of mother-to-child transmission (PMTCT). Suboptimal responses to treatment observed post-PMTCT interventions necessitated the need to investigate the profile of viral mutations generated. This study investigated HIV-1 drug resistance profiles in mothers in selected centres in Ghana on treatment with a history of prophylaxis. METHODS: Genotypic Drug Resistance Testing for HIV-1 was carried out. Subtyping was done by phylogenetic analysis and Stanford HIV Database programme was used for drug resistance analysis and interpretation. To compare the significance between the different groups and the emergence of drug resistance mutations, p values were used. RESULTS: Participants who had prophylaxis before treatment, those who had treatment without prophylaxis and those yet to initiate PMTCT showed 32% (8), 5% (3) and 15% (4) HIV-1 drug resistance associated mutations respectively. The differences were significant with p value < 0.05. Resistance Associated Mutations (RAMs) were seen in 14 participants (35%) to nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). The most common NRTI mutation found was M184 V; K103 N and A98G were the most common NNRTI mutations seen. Thymidine Analogue Mutations (TAMs) such as M41 L, K70R and T215Y were found in all the groups; the most common of the TAMs found were M41 L and T215Y. Majority of the subtypes were CRF02_AG (82%). CONCLUSION: In Ghana initiation of uninterrupted treatment upon diagnosis, coupled with drug resistance testing, would produce a better treatment outcome for HIV-1 positive pregnant women.es_ES
dc.description.sponsorshipThere was no external institutional funding for this study.es_ES
dc.publisherBioMed Central (BMC) es_ES
dc.subjectAntiretroviral therapyes_ES
dc.subjectDrug resistance profileses_ES
dc.subjectPhylogenetic analysises_ES
dc.subjectTreatment outcomees_ES
dc.subject.meshAnti-HIV Agents es_ES
dc.subject.meshChemoprevention es_ES
dc.subject.meshFemale es_ES
dc.subject.meshGenotype es_ES
dc.subject.meshGhana es_ES
dc.subject.meshHIV Infections es_ES
dc.subject.meshHIV-1 es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInfectious Disease Transmission, Verticales_ES
dc.subject.meshMothers es_ES
dc.subject.meshPhylogeny es_ES
dc.subject.meshPregnancy es_ES
dc.subject.meshPregnancy Complications, Infectious es_ES
dc.subject.meshSequence Analysis, DNA es_ES
dc.subject.meshTreatment Outcome es_ES
dc.subject.meshDrug Resistance, Viral es_ES
dc.subject.meshMutation, Missense es_ES
dc.titleEmergence of HIV-1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghanaes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.journalVirology journales_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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Atribución 4.0 Internacional
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