Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/7379
Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens
Martinez, Isidoro ISCIII | Oliveros, Juan C. | Cuesta, Isabel ISCIII | de la Barrera, Jorge CNIC | Ausina, Vicente | Casals, Cristina | de Lorenzo, Alba | García, Ernesto | García-Fojeda, Belén | Garmendia, Junkal | González-Nicolau, Mar | Lacoma, Alicia | Menéndez, Margarita | Moranta, David | Nieto, Amelia | Ortín, Juan | Pérez-González, Alicia | Prat-Vidal, Cristina CNIC | Ramos-Sevillano, Elisa ISCIII | Regueiro, Verónica | Rodriguez-Frandsen, Ariel | Solís, Dolores | Yuste, Jose Enrique ISCIII | Bengoechea, José A. | Melero, Jose Antonio ISCIII
Front Microbiol. 2017 Mar:276.
Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here.
Bacterial infections | Core of up-regulated genes | Host response | Respiratory pathogens | Viral infections
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