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dc.contributor.authorLolo, Fidel Nicolas 
dc.contributor.authorRius, Cristina 
dc.contributor.authorCasas-Tintó, Sergio
dc.date.accessioned2019-03-07T13:40:30Z
dc.date.available2019-03-07T13:40:30Z
dc.date.issued2017-12-15
dc.identifier.citationBiol Open. 2017; 6(12):1897-1903es_ES
dc.identifier.issn2046-6390es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7302
dc.description.abstractCellular interactions are critical during development, tissue fitness and epithelial tumor development. The expression levels of specific genes confer to tumoral cells a survival advantage versus the normal neighboring cells. As a consequence, cells surrounding tumors are eliminated and engulfed by macrophages. We propose a novel scenario in which circulating cells facing a tumor can reproduce these cellular interactions. In vitro cultured macrophages from murine bone marrow were used to investigate this hypothesis. M1 macrophages in tumoral medium upregulated markers of a suboptimal condition, such as Sparc and TyrRS, and undergo apoptosis. However, M2 macrophages display higher Myc expression levels and proliferate at the expense of M1. Resulting M1 apoptotic debris is engulfed by M2 in a Sparc- and TyrRS-dependent manner. These findings suggest that tumor-dependent macrophage elimination could deplete immune response against tumors. This possibility could be relevant for macrophage based anti-tumoral strategies.es_ES
dc.description.sponsorshipThis work was supported by Ministerio de Economı́a y Competitividad (RyC-2012-11410 and BFU2015-65685P to S.C.-T.) and Fundación Jesús Serra.es_ES
dc.language.isoenges_ES
dc.publisherThe Company of Biologists es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAlternatively-activated macrophageses_ES
dc.subjectApoptosises_ES
dc.subjectClassically-activated macrophageses_ES
dc.subjectTumoral environmentes_ES
dc.titleElimination of classically-activated macrophages in tumor-conditioned medium by alternatively-activated macrophageses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29162623es_ES
dc.format.volume6es_ES
dc.format.number12es_ES
dc.format.page1897-1903es_ES
dc.identifier.doi10.1242/bio.027300es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderFundación Jesús Serra
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1242/bio.027300es_ES
dc.identifier.journalBiology openes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Señalización por Integrinases_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RyC-2012-11410es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2015-65685Pes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
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