Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7302
Título
Elimination of classically-activated macrophages in tumor-conditioned medium by alternatively-activated macrophages
Autor(es)
Fecha de publicación
2017-12-15
Cita
Biol Open. 2017; 6(12):1897-1903
Idioma
Inglés
Tipo de documento
journal article
Resumen
Cellular interactions are critical during development, tissue fitness and epithelial tumor development. The expression levels of specific genes confer to tumoral cells a survival advantage versus the normal neighboring cells. As a consequence, cells surrounding tumors are eliminated and engulfed by macrophages. We propose a novel scenario in which circulating cells facing a tumor can reproduce these cellular interactions. In vitro cultured macrophages from murine bone marrow were used to investigate this hypothesis. M1 macrophages in tumoral medium upregulated markers of a suboptimal condition, such as Sparc and TyrRS, and undergo apoptosis. However, M2 macrophages display higher Myc expression levels and proliferate at the expense of M1. Resulting M1 apoptotic debris is engulfed by M2 in a Sparc- and TyrRS-dependent manner. These findings suggest that tumor-dependent macrophage elimination could deplete immune response against tumors. This possibility could be relevant for macrophage based anti-tumoral strategies.
Palabras clave
Alternatively-activated macrophages | Apoptosis | Classically-activated macrophages | Tumoral environment
Versión en línea
DOI
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