Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/7252
Monocyte Chemotactic Protein 1 in Plasma from Soluble Leishmania Antigen-Stimulated Whole Blood as a Potential Biomarker of the Cellular Immune Response to Leishmania infantum
Ibarra-Meneses, Ana Victoria ISCIII | Sanchez Herrero, Carmen ISCIII | Alvar, Jorge ISCIII | Moreno, Javier ISCIII | Carrillo, Eugenia ISCIII
Front Immunol. 2017 Sep 29;8:1208.
New biomarkers are needed to identify asymptomatic Leishmania infection as well as immunity following vaccination or treatment. With the aim of finding a robust biomarker to assess an effective cellular immune response, monocyte chemotactic protein 1 (MCP-1) was examined in plasma from soluble Leishmania antigen (SLA)-stimulated whole blood collected from subjects living in a Leishmania infantum-endemic area. MCP-1, expressed 110 times more strongly than IL-2, identified 87.5% of asymptomatic subjects and verified some asymptomatic subjects close to the cutoff. MCP-1 was also significantly elevated in all patients cured of visceral leishmaniasis (VL), unlike IL-2, indicating the specific memory response generated against Leishmania. These results show MCP-1 to be a robust candidate biomarker of immunity that could be used as a marker of cure and to both select and follow the population in vaccine phase I-III human clinical trials with developed rapid, easy-to-use field tools.
Asymptomatic infection | Biomarker | Chemokines | Cytokines | Leishmaniasis | Monocyte chemotactic protein 1 | Treatment | Whole blood assay
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