Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7204
Título
Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons
Autor(es)
Fecha de publicación
2017
Cita
Cell Rep. 2017 ;18(5):1157-1170.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Neural circuits in the cerebral cortex consist of excitatory pyramidal cells and inhibitory interneurons. These two main classes of cortical neurons follow largely different genetic programs, yet they assemble into highly specialized circuits during development following a very precise choreography. Previous studies have shown that signals produced by pyramidal cells influence the migration of cortical interneurons, but the molecular nature of these factors has remained elusive. Here, we identified Neuregulin 3 (Nrg3) as a chemoattractive factor expressed by developing pyramidal cells that guides the allocation of cortical interneurons in the developing cortical plate. Gain- and loss-of-function approaches reveal that Nrg3 modulates the migration of interneurons into the cortical plate in a process that is dependent on the tyrosine kinase receptor ErbB4. Perturbation of Nrg3 signaling in conditional mutants leads to abnormal lamination of cortical interneurons. Nrg3 is therefore a critical mediator in the assembly of cortical inhibitory circuits.
Palabras clave
Erbb4 | GABA | Cerebral cortex | Cortical plate | Inhibition | Interneuron | Lamination | Migration | Neuregulins | Pyramidal cell
MESH
Animals | Cell Movement | Cerebral Cortex | GABAergic Neurons | Interneurons | Intracellular Signaling Peptides and Proteins | Mice | Mice, Inbred C57BL | Pyramidal Cells | Receptor Protein-Tyrosine Kinases | Receptor, ErbB-4 | Signal Transduction
Versión en línea
DOI
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