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dc.contributor.authorTrento, Alfonsina 
dc.contributor.authorRodríguez-Fernández, Rosa
dc.contributor.authorGonzález-Sánchez, María I
dc.contributor.authorGonzález-Martínez, Felipe
dc.contributor.authorMas-Lloret, Vicente 
dc.contributor.authorVazquez-Alcaraz, Monica 
dc.contributor.authorPalomo-Sanz, Concepcion 
dc.contributor.authorMelero, Jose Antonio 
dc.date.accessioned2019-02-20T11:33:09Z
dc.date.available2019-02-20T11:33:09Z
dc.date.issued2017-11
dc.identifier.citationFront Microbiol. 2017 Nov 22;8:2301.es_ES
dc.identifier.issn1664-302Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7193
dc.description.abstractThe influence of age and maternal antibodies on the antibody responses to human respiratory syncytial virus (hRSV) glycoproteins in very young children has been a matter of controversy. Both, immaturity of the immune system at very early age and suppression of the host immune response by high level of maternal antibodies have been claimed to limit the host antibody response to virus infection and to jeopardize the use of hRSV vaccines under development in that age group. Hence, the antibody responses to the two major hRSV glycoproteins (F and G) were evaluated in children younger than 2 years, hospitalized with laboratory confirmed hRSV bronchiolitis. A strong negative correlation was found between the titre of circulating ELISA antibodies directed against either prefusion or postfusion F in the acute phase, but not age, and their fold change at convalescence. These changes correlated also with the level of circulating neutralizing antibodies in sera. As reported in adults, most neutralizing antibodies in a subset of tested sera could not be depleted with postfusion F, suggesting that they were mostly directed against prefusion-specific epitopes. In contrast, a weak negative association was found for group-specific anti-G antibodies in the acute phase and their fold change at convalescence only after correcting for the antigenic group of the infecting virus. In addition, large discrepancies were observed in some individuals between the antibody responses specific for F and G glycoproteins. These results illustrate the complexity of the anti-hRSV antibody responses in children experiencing a primary severe infection and the influence of preexisting maternal antibodies on the host response, factors that should influence hRSV serological studies as well as vaccine development.es_ES
dc.description.sponsorshipThis work was supported in part by grants SAF2015-67033-R from Plan Nacional I+D+I (JM) and PI16/00822 from Fondo de Investigaciones Sanitarias (RR-F).es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAntibody specificityes_ES
dc.subjectBronchiolitises_ES
dc.subjectGlycoproteinses_ES
dc.subjectImmune responseses_ES
dc.subjectRespiratory syncytial virus infectionses_ES
dc.subjectVirales_ES
dc.titleThe Complexity of Antibody Responses Elicited against the Respiratory Syncytial Virus Glycoproteins in Hospitalized Children Younger than 2 Yearses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29213258es_ES
dc.format.volume8es_ES
dc.format.page2301es_ES
dc.identifier.doi10.3389/fmicb.2017.02301es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderFondo de Investigaciones Sanitarias
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fmicb.2017.02301es_ES
dc.identifier.journalFrontiers in microbiologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-67033-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI16/00822es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
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