Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7185
Título
A Two-Dimensional Human Minilung System (Model) for Respiratory Syncytial Virus Infections
Autor(es)
Magro-Lopez, Esmeralda ISCIII | Guijarro, Trinidad ISCIII | Martinez, Isidoro ISCIII | Martin-Vicente, Maria ISCIII | Liste-Noya, Isabel ISCIII | Zambrano, Alberto ISCIII
Fecha de publicación
2017-12-10
Cita
Viruses. 2017 Dec 10;9(12). pii: E379.
Idioma
Inglés
Tipo de documento
research article
Resumen
Human respiratory syncytial virus (HRSV) is a major cause of serious pediatric respiratory diseases that lacks effective vaccine or specific therapeutics. Although our understanding about HRSV biology has dramatically increased during the last decades, the need for adequate models of HRSV infection is compelling. We have generated a two-dimensional minilung from human embryonic stem cells (hESCs). The differentiation protocol yielded at least six types of lung and airway cells, although it is biased toward the generation of distal cells. We show evidence of HRSV replication in lung cells, and the induction of innate and proinflammatory responses, thus supporting its use as a model for the study of HRSV-host interactions.
Palabras clave
MESH
Cell Differentiation | Human Embryonic Stem Cells | Humans | Immunity, Innate | Lung | Organ Culture Techniques | Respiratory Syncytial Virus Infections | Respiratory Syncytial Virus, Human | Virus Replication | Models, Theoretical
Versión en línea
DOI
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