Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/7185
A Two-Dimensional Human Minilung System (Model) for Respiratory Syncytial Virus Infections
Viruses. 2017 Dec 10;9(12). pii: E379.
Human respiratory syncytial virus (HRSV) is a major cause of serious pediatric respiratory diseases that lacks effective vaccine or specific therapeutics. Although our understanding about HRSV biology has dramatically increased during the last decades, the need for adequate models of HRSV infection is compelling. We have generated a two-dimensional minilung from human embryonic stem cells (hESCs). The differentiation protocol yielded at least six types of lung and airway cells, although it is biased toward the generation of distal cells. We show evidence of HRSV replication in lung cells, and the induction of innate and proinflammatory responses, thus supporting its use as a model for the study of HRSV-host interactions.
Cell Differentiation | Human Embryonic Stem Cells | Humans | Immunity, Innate | Lung | Organ Culture Techniques | Respiratory Syncytial Virus Infections | Respiratory Syncytial Virus, Human | Virus Replication | Models, Theoretical
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