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dc.contributor.authorJimenez-Sousa, Maria Angeles 
dc.contributor.authorFernandez-Rodriguez, Amanda 
dc.contributor.authorGuzman-Fulgencio, Maria 
dc.contributor.authorGarcia-Alvarez, Monica 
dc.contributor.authorResino, Salvador
dc.identifier.citationBMC Med. 2013 Jan 8;11:6.es_ES
dc.description.abstractBACKGROUND: Since 2009, several studies have identified single-nucleotide polymorphisms (SNPs) near the gene encoding for interleukin (IL)-28 (IL28B) that are strongly associated with spontaneous and treatment-induced hepatitis C virus (HCV) clearance. Because this large amount of data includes some inconsistencies, we consider assessment of the global estimate for each SNP to be essential. METHODS: Relevant studies assessing IL28B polymorphisms associated with sustained virologic response (SVR) and spontaneous clearance (SC) were identified from a literature search of PubMed up to 9 July, 2012. Studies were eligible studies if they included patients infected with HCV or HCV/HIV, or assessed any SNP located within or near the IL28B gene, SVR data available under standard treatment, and/or SC data in patients with acute HCV infection. Pooled odds ratios were estimated by fixed or random effects models when appropriate. Variables such as HCV genotype, ethnicity, and type of co-infection were studied. RESULTS: Of 282 screened studies, 67 were selected for SVR and 10 for SC. In total, 20,163 patients were studied for SVR and 3,554 for SC. For SVR, we found that all SNPs showed strong associations in patients with HCV genotypes 1 and 4, whereas the pooled ORs were almost three times lower for genotypes 2 and 3 (rs12979860 and rs8099917). Regarding ethnicity, the SNP most associated with SVR was rs12979860 in white patients, whereas in East Asians it seemed to be rs8099917. The most studied SNP (rs12979860) showed similar results for patients co-infected with HCV/HIV, as for those infected with HCV only. Finally, rs12979860 and rs8099917 both appeared to be associated with SC. CONCLUSIONS: IL28B polymorphisms influence both the outcome of interferon treatment and the natural clearance of HCV. However we did not identify a universal predictor SNP, as the best genetic markers differed depending on patient ethnicity, genotype, and type of infection. Nevertheless, our results may be useful for more precise treatment decision-making.es_ES
dc.description.sponsorshipThis work was supported by grants from the 'Health Institute Carlos III (ISCIII)' [PI08/0738 and PI11/00245]. MAJS, AFR MGF and MGA were supported by the after grants [CM10/00105, PI08/0738, CM09/00031, and CM08/00101 respectively].es_ES
dc.publisherBioMed Central (BMC) es_ES
dc.subjectSystematic reviewes_ES
dc.subjectInterleukin 28Bes_ES
dc.subject.meshAntiviral Agents es_ES
dc.subject.meshEthnic Groups es_ES
dc.subject.meshGenotype es_ES
dc.subject.meshHepatitis C es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInterferons es_ES
dc.subject.meshInterleukins es_ES
dc.subject.meshTreatment Outcome es_ES
dc.subject.meshPolymorphism, Single Nucleotide es_ES
dc.titleMeta-analysis: implications of interleukin-28B polymorphisms in spontaneous and treatment-related clearance for patients with hepatitis Ces_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III 
dc.identifier.journalBMC medicinees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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