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dc.contributor.author | Lopez-Abente, Gonzalo | |
dc.contributor.author | Aragones, Nuria | |
dc.contributor.author | Perez-Gomez, Beatriz | |
dc.contributor.author | Pollan-Santamaria, Marina | |
dc.contributor.author | García-Pérez, Javier | |
dc.contributor.author | Ramis, Rebeca | |
dc.contributor.author | Fernandez-Navarro, Pablo L | |
dc.date.accessioned | 2019-02-01T19:08:00Z | |
dc.date.available | 2019-02-01T19:08:00Z | |
dc.date.issued | 2014-07-24 | |
dc.identifier.citation | BMC Cancer. 2014 Jul 24;14:535. | es_ES |
dc.identifier.issn | 1471-2407 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7075 | |
dc.description.abstract | BACKGROUND: New disease mapping techniques widely used in small-area studies enable disease distribution patterns to be identified and have become extremely popular in the field of public health. This paper reports on trends in the geographical mortality patterns of the most frequent cancers in Spain, over a period of 20 years. METHODS: We studied the municipal spatial pattern of stomach, colorectal, lung, breast, prostate and urinary bladder cancer mortality in Spain across four quinquennia, spanning the period 1989-2008. Case data were broken down by town (8073 municipalities), period and sex. Expected cases for each town were calculated using reference rates for each five-year period. For map plotting purposes, smoothed municipal relative risks were calculated using the conditional autoregressive model proposed by Besag, York and Mollié, with independent data for each quinquennium. We evaluated the presence of spatial patterns in maps on the basis of models, calculating the variance in relative risk corresponding to the structured spatial component and the unstructured component, as well as the proportion of variance explained by the structured spatial component. RESULTS: The mortality patterns observed for stomach, colorectal and lung cancer were maintained over the 20 years covered by the study. Prostate cancer and the tumours studied in women showed no defined spatial pattern, with the single exception of stomach cancer. The trend in spatial fractional variance indicated the possibility of a change in the spatial pattern in breast, bladder and colorectal cancer in women during the last five-year period. The paper goes on to discuss ways in which spatio-temporal data are depicted in the case of cancer, and review the risk factors that may possibly influence the respective tumours' spatial patterns. CONCLUSION: In men, the marked geographical patterns of stomach, colorectal, lung and bladder cancer remained stable over time. Breast, colorectal and bladder cancer in women show signs of the possible appearance of a spatial pattern in Spain and should therefore be monitored. | es_ES |
dc.description.sponsorship | The study was partially supported by a research grant from the Spanish Health Research Fund (FIS PI11/00871). Mortality data were supplied by the Spanish National Statistics Institute in accordance with a specific confidentiality protocol. Thanks to Olivier Nuñez for his comments about interpretation of some aspects of models results. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BioMed Central (BMC) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Age Factors | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Geographic Mapping | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Neoplasms | es_ES |
dc.subject.mesh | Risk Factors | es_ES |
dc.subject.mesh | Sex Factors | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.subject.mesh | Time Factors | es_ES |
dc.title | Time trends in municipal distribution patterns of cancer mortality in Spain | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 25060700 | es_ES |
dc.format.volume | 14 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 535 | es_ES |
dc.identifier.doi | 10.1186/1471-2407-14-535 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1471-2407 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1186/1471-2407-14-535 | es_ES |
dc.identifier.journal | BMC cancer | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |