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dc.contributor.authorMarín, Alejandro
dc.contributor.authorMedrano, Maria Jose 
dc.contributor.authorGonzález, José
dc.contributor.authorPintado, Héctor
dc.contributor.authorCompaired, Vicente
dc.contributor.authorBárcena, Mario
dc.contributor.authorFustero, María Victoria
dc.contributor.authorTisaire, Javier
dc.contributor.authorCucalón, José M
dc.contributor.authorMartín, Aurelio
dc.contributor.authorBoix Martinez, Raquel 
dc.contributor.authorHernansanz, Francisco
dc.contributor.authorBueno, José
dc.date.accessioned2019-02-01T13:55:21Z
dc.date.available2019-02-01T13:55:21Z
dc.date.issued2006-02-17
dc.identifier.citationBMC Public Health. 2006 Feb 17;6:38.es_ES
dc.identifier.issn1471-2458es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7058
dc.description.abstractBACKGROUND: Ischaemic heart disease is a global priority of health-care policy, because of its social repercussions and its impact on the health-care system. Yet there is little information on coronary morbidity in Spain and on the effect of the principal risk factors on risk of coronary heart disease. The objective of this study is to describe the epidemiology of coronary disease (incidence, mortality and its association with cardiovascular risk factors) using the information gathered by primary care practitioners on cardiovascular health of their population. METHODS: A prospective study was designed. Eight primary-care centres participated, each contributing to the constitution of the cohort with the entire population covered by the centre. A total of 6124 men and women aged over 25 years and free of cardiovascular disease agreed to participate and were thus enrolled and followed-up, with all fatal and non-fatal coronary disease episodes being registered during a 5-year period. Repeated measurements were collected on smoking, blood pressure, weight and height, serum total cholesterol, high-density and low-density lipoproteins and fasting glucose. Rates were calculated for acute myocardial infarction and ischaemic heart disease. Associations between cardiovascular risk factors and coronary disease-free survival were evaluated using Kaplan-Meier and Cox regression analyses. RESULTS: Mean age at recruitment was 51.6 +/- 15, with 24% of patients being over 65. At baseline, 74% of patients were overweight, serum cholesterol over 240 was present in 35% of patients, arterial hypertension in 37%, and basal glucose over 126 in 11%. Thirty-four percent of men and 13% of women were current smokers. During follow-up, 155 first episodes of coronary disease were detected, which yielded age-adjusted rates of 362 and 191 per 100,000 person-years in men and women respectively. Disease-free survival was associated with all risk factors in univariate analyses. After multivariate adjustments, age, male gender, smoking, high total cholesterol, high HDL/LDL ratio, diabetes and overweight remained strongly associated with risk. Relative risks for hypertension in women and for diabetes in men did not reach statistical significance. CONCLUSION: Despite high prevalence of vascular risk factors, incidence rates were lower than those reported for other countries and other periods, but similar to those reported in the few population-based studies in Spain. Effect measures of vascular risk factors were mainly as reported worldwide and support the hypothesis that protective factors not considered in this study must exist as to explain low rates. This study shows the feasibility of conducting epidemiological cohort studies in primary-care settings.es_ES
dc.language.isoenges_ES
dc.publisherBioMed Central (BMC) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAdult es_ES
dc.subject.meshAged es_ES
dc.subject.meshBlood Glucose es_ES
dc.subject.meshCholesterol es_ES
dc.subject.meshDisease-Free Survival es_ES
dc.subject.meshEpidemiologic Studies es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshHypertension es_ES
dc.subject.meshLife Style es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshMyocardial Infarction es_ES
dc.subject.meshMyocardial Ischemia es_ES
dc.subject.meshPrevalence es_ES
dc.subject.meshPrimary Health Care es_ES
dc.subject.meshProportional Hazards Models es_ES
dc.subject.meshProspective Studies es_ES
dc.subject.meshRisk Factors es_ES
dc.subject.meshSpain es_ES
dc.subject.meshEpisode of Care es_ES
dc.subject.meshRisk Assessment es_ES
dc.titleRisk of ischaemic heart disease and acute myocardial infarction in a Spanish population: observational prospective study in a primary-care settinges_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID16503965es_ES
dc.format.volume6es_ES
dc.format.number1es_ES
dc.format.page38es_ES
dc.identifier.doi10.1186/1471-2458-6-38es_ES
dc.contributor.funderLaboratorios Parke-Davis 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1471-2458es_ES
dc.relation.publisherversionhttps://doi.org/10.1186/1471-2458-6-38es_ES
dc.identifier.journalBMC public healthes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional