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dc.contributor.authorSobrino-Vegas, Paz 
dc.contributor.authorPérez-Hoyos, Santiago
dc.contributor.authorGeskus, Ronald
dc.contributor.authorPadilla, Belén
dc.contributor.authorSegura, Ferrán
dc.contributor.authorRubio, Rafael
dc.contributor.authorDel Romero, Jorge
dc.contributor.authorSantos, Jesus
dc.contributor.authorMoreno, Santiago
dc.contributor.authorAmo, Julia del
dc.identifier.citationAIDS Res Treat. 2012; 2012: 725412.es_ES
dc.description.abstractObjectives. Since subjects may have been diagnosed before cohort entry, analysis of late HIV diagnosis (LD) is usually restricted to the newly diagnosed. We estimate the magnitude and risk factors of LD in a cohort of seroprevalent individuals by imputing seroconversion dates. Methods. Multicenter cohort of HIV-positive subjects who were treatment naive at entry, in Spain, 2004-2008. Multiple-imputation techniques were used. Subjects with times to HIV diagnosis longer than 4.19 years were considered LD. Results. Median time to HIV diagnosis was 2.8 years in the whole cohort of 3,667 subjects. Factors significantly associated with LD were: male sex; Sub-Saharan African, Latin-American origin compared to Spaniards; and older age. In 2,928 newly diagnosed subjects, median time to diagnosis was 3.3 years, and LD was more common in injecting drug users. Conclusions. Estimates of the magnitude and risk factors of LD for the whole cohort differ from those obtained for new HIV diagnoses.es_ES
dc.description.sponsorshipThe authors acknowledge that this study would not have been possible without the collaboration of all the patients, physicians, nurses, and data managers who have taken part in the project. They want to thank Dr. P. Alcamí for his help in immunological interpretation. CoRIS members belong to Cohorte de la Red de Investigación en Sida, Spaines_ES
dc.publisherHindawi es_ES
dc.titleImputation of the Date of HIV Seroconversion in a Cohort of Seroprevalent Subjects: Implications for Analysis of Late HIV Diagnosises_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-4.0 Internacional*
dc.identifier.journalAIDS research and treatmentes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES
dc.rights.accessRightsopen accesses_ES

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